GBRA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRA2_HUMAN
• UniProt AC: P47869
• Protein Name: Gamma-aminobutyric acid receptor subunit alpha-2
• Gene Name: GABRA2
• Organism: Homo sapiens (Human).
• Sequence Length: 451
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
• Protein Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..
• Protein Sequence: MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15 (in isoform 2)	Phosphorylation	-	3.87	26552605
21 (in isoform 2)	Phosphorylation	-	21.36	26552605
32 (in isoform 2)	Phosphorylation	-	54.76	26552605
33 (in isoform 2)	Phosphorylation	-	44.79	26552605
38	N-linked_Glycosylation	QEDEAKNNITIFTRI CCHHHHCCCCHHHHH	31.88	UniProtKB CARBOHYD
53	Phosphorylation	LDRLLDGYDNRLRPG HHHHHCCCCCCCCCC	15.09	18083107
64	Phosphorylation	LRPGLGDSITEVFTN CCCCCCHHHHHHHCC	29.61	26552605
66	Phosphorylation	PGLGDSITEVFTNIY CCCCHHHHHHHCCEE	30.01	26552605
70	Phosphorylation	DSITEVFTNIYVTSF HHHHHHHCCEEEEEE	26.36	26552605
73	Phosphorylation	TEVFTNIYVTSFGPV HHHHCCEEEEEECCC	10.35	26552605
75	Phosphorylation	VFTNIYVTSFGPVSD HHCCEEEEEECCCCC	11.02	26552605
76	Phosphorylation	FTNIYVTSFGPVSDT HCCEEEEEECCCCCC	20.40	26552605
81	Phosphorylation	VTSFGPVSDTDMEYT EEEECCCCCCCCEEE	37.62	26552605
83	Phosphorylation	SFGPVSDTDMEYTID EECCCCCCCCEEEEE	29.73	26552605
87	Phosphorylation	VSDTDMEYTIDVFFR CCCCCCEEEEEEEHH	11.45	26552605
88	Phosphorylation	SDTDMEYTIDVFFRQ CCCCCEEEEEEEHHH	9.44	26552605
101	Methylation	RQKWKDERLKFKGPM HHHCCCCCCCCCCCC	54.00	-
138	N-linked_Glycosylation	GKKSVAHNMTMPNKL CCCCCEECCCCCCCE	20.20	UniProtKB CARBOHYD
232	Phosphorylation	IGKETIKSSTGEYTV CCCHHHHHCCCCEEE	29.31	26552605
233	Phosphorylation	GKETIKSSTGEYTVM CCHHHHHCCCCEEEE	35.11	26552605
234	Phosphorylation	KETIKSSTGEYTVMT CHHHHHCCCCEEEEE	40.92	26552605
237	Phosphorylation	IKSSTGEYTVMTAHF HHHCCCCEEEEEEEE	13.13	26552605
238	Phosphorylation	KSSTGEYTVMTAHFH HHCCCCEEEEEEEEH	10.25	26552605
241	Phosphorylation	TGEYTVMTAHFHLKR CCCEEEEEEEEHHHC	16.79	26552605
278	Phosphorylation	SFWLNRESVPARTVF HHHHCCCCCCHHHCC	30.11	-
385	Phosphorylation	LSKDPVLSTISKSAT CCCCCCHHHCCCCCC	24.75	-
386	Phosphorylation	SKDPVLSTISKSATT CCCCCHHHCCCCCCC	25.72	-
388	Phosphorylation	DPVLSTISKSATTPE CCCHHHCCCCCCCCC	22.20	-
439	Phosphorylation	FNLVYWATYLNREPV HHHHHHHHHCCCCCC	17.88	24719451
440	Phosphorylation	NLVYWATYLNREPVL HHHHHHHHCCCCCCC	8.33	24719451
450	Phosphorylation	REPVLGVSP------ CCCCCCCCC------	24.08	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBRA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRA2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.