| UniProt ID | TMUB2_HUMAN | |
|---|---|---|
| UniProt AC | Q71RG4 | |
| Protein Name | Transmembrane and ubiquitin-like domain-containing protein 2 | |
| Gene Name | TMUB2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 321 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | ||
| Protein Sequence | MISRHLQNNLMSVDPASSQAMELSDVTLIEGVGNEVMVVAGVVVLILALVLAWLSTYVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPSLGVNVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 120 | Phosphorylation | AGEGRGDSTGEAGAG HCCCCCCCCCCCCCC | 40.93 | 21712546 | |
| 121 | Phosphorylation | GEGRGDSTGEAGAGG CCCCCCCCCCCCCCC | 43.72 | 21712546 | |
| 125 (in isoform 3) | Ubiquitination | - | 22.05 | 21890473 | |
| 125 (in isoform 2) | Ubiquitination | - | 22.05 | 21890473 | |
| 145 | Ubiquitination | LDIQGLPKRQAGAGS HHHCCCCHHCCCCCC | 63.28 | 21890473 | |
| 145 (in isoform 1) | Ubiquitination | - | 63.28 | 21890473 | |
| 152 | Phosphorylation | KRQAGAGSSSPEAPL HHCCCCCCCCCCCCC | 27.40 | 29255136 | |
| 153 | Phosphorylation | RQAGAGSSSPEAPLR HCCCCCCCCCCCCCC | 49.33 | 29255136 | |
| 154 | Phosphorylation | QAGAGSSSPEAPLRS CCCCCCCCCCCCCCC | 28.58 | 29255136 | |
| 159 (in isoform 2) | Ubiquitination | - | 14.00 | 21890473 | |
| 159 (in isoform 3) | Ubiquitination | - | 14.00 | 21890473 | |
| 164 | Phosphorylation | APLRSEDSTCLPPSP CCCCCCCCCCCCCCC | 19.57 | 25159151 | |
| 165 | Phosphorylation | PLRSEDSTCLPPSPG CCCCCCCCCCCCCCC | 30.31 | 25627689 | |
| 170 | Phosphorylation | DSTCLPPSPGLITVR CCCCCCCCCCEEEEE | 29.65 | 21815630 | |
| 179 | Ubiquitination | GLITVRLKFLNDTEE CEEEEEEEECCCCHH | 36.92 | 21890473 | |
| 179 (in isoform 1) | Ubiquitination | - | 36.92 | 21890473 | |
| 180 (in isoform 2) | Ubiquitination | - | 10.24 | 21890473 | |
| 192 (in isoform 2) | Ubiquitination | - | 33.79 | 21890473 | |
| 200 | Ubiquitination | EDTVGALKSKYFPGQ CCHHHHHHHCCCCCC | 44.35 | 21906983 | |
| 200 (in isoform 1) | Ubiquitination | - | 44.35 | 21890473 | |
| 202 | Ubiquitination | TVGALKSKYFPGQES HHHHHHHCCCCCCHH | 49.69 | - | |
| 212 | Ubiquitination | PGQESQMKLIYQGRL CCCHHHHHHHHCCCC | 24.89 | 21890473 | |
| 212 (in isoform 1) | Ubiquitination | - | 24.89 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMUB2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMUB2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMUB2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MBRL_HUMAN | TMEM259 | physical | 28514442 | |
| ERLN1_HUMAN | ERLIN1 | physical | 28514442 | |
| TMUB1_HUMAN | TMUB1 | physical | 28514442 | |
| ERLN2_HUMAN | ERLIN2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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