GBRA3_HUMAN - dbPTM
GBRA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBRA3_HUMAN
UniProt AC P34903
Protein Name Gamma-aminobutyric acid receptor subunit alpha-3
Gene Name GABRA3
Organism Homo sapiens (Human).
Sequence Length 492
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein.
Protein Description GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..
Protein Sequence MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MIITQTSHCYM
----CCEECCCCEEH		18.1820049867
6Phosphorylation--MIITQTSHCYMTS
--CCEECCCCEEHHH		16.2820049867
7Phosphorylation-MIITQTSHCYMTSL
-CCEECCCCEEHHHH		11.1820049867
10PhosphorylationITQTSHCYMTSLGIL
EECCCCEEHHHHHHH		9.6720049867
12PhosphorylationQTSHCYMTSLGILFL
CCCCEEHHHHHHHHH		8.3720049867
13PhosphorylationTSHCYMTSLGILFLI
CCCEEHHHHHHHHHH		14.2020049867
63N-linked_GlycosylationIPDDSTDNITIFTRI
CCCCCCCCCHHHHHH		33.13UniProtKB CARBOHYD
78PhosphorylationLDRLLDGYDNRLRPG
HHHHHCCCCCCCCCC		15.0918083107
91PhosphorylationPGLGDAVTEVKTDIY
CCCCHHHCEEECCEE		36.46-
95PhosphorylationDAVTEVKTDIYVTSF
HHHCEEECCEEEEEE		32.57-
98PhosphorylationTEVKTDIYVTSFGPV
CEEECCEEEEEECCC		10.65-
163N-linked_GlycosylationGKKSVAHNMTTPNKL
CCCCCCCCCCCCCHH		21.54UniProtKB CARBOHYD
166PhosphorylationSVAHNMTTPNKLLRL
CCCCCCCCCCHHEEE		17.6927251275
176N-linked_GlycosylationKLLRLVDNGTLLYTM
HHEEEEECCEEEEEE		37.56UniProtKB CARBOHYD
178PhosphorylationLRLVDNGTLLYTMRL
EEEEECCEEEEEEEE		21.6129255136
181PhosphorylationVDNGTLLYTMRLTIH
EECCEEEEEEEEEEE		11.1229255136
182PhosphorylationDNGTLLYTMRLTIHA
ECCEEEEEEEEEEEE		8.8629255136
228N-linked_GlycosylationYSWTLGKNKSVEVAQ
EEEECCCCCEEEEEC		39.78UniProtKB CARBOHYD
257PhosphorylationVGTEIIRSSTGEYVV
HCCCHHHCCCCCEEE		23.11-
258PhosphorylationGTEIIRSSTGEYVVM
CCCHHHCCCCCEEEE		30.5025307156
259PhosphorylationTEIIRSSTGEYVVMT
CCHHHCCCCCEEEEE		34.9725307156
262PhosphorylationIRSSTGEYVVMTTHF
HHCCCCCEEEEEEEH		10.3325307156
303PhosphorylationSFWLNRESVPARTVF
HHHHCCCCCCHHHCC		30.11-
384PhosphorylationALEMKKKTPAAPAKK
HHHHHCCCCCCCCCC		27.34-
423PhosphorylationISKGAAPSASSTPTI
ECCCCCCCCCCCCEE		35.7425693802
425PhosphorylationKGAAPSASSTPTIIA
CCCCCCCCCCCEEEE		38.8024076635
426PhosphorylationGAAPSASSTPTIIAS
CCCCCCCCCCEEEEC		37.8225693802
427PhosphorylationAAPSASSTPTIIASP
CCCCCCCCCEEEECC		23.1924076635
429PhosphorylationPSASSTPTIIASPKA
CCCCCCCEEEECCCC		25.7125693802
433PhosphorylationSTPTIIASPKATYVQ
CCCEEEECCCCEEEC		19.2725693802
442PhosphorylationKATYVQDSPTETKTY
CCEEECCCCCCCCCC		19.3424076635
444PhosphorylationTYVQDSPTETKTYNS
EEECCCCCCCCCCCC		61.3125332170
448PhosphorylationDSPTETKTYNSVSKV
CCCCCCCCCCCCCHH		35.0429978859
449PhosphorylationSPTETKTYNSVSKVD
CCCCCCCCCCCCHHH		13.6529978859
451PhosphorylationTETKTYNSVSKVDKI
CCCCCCCCCCHHHHH		19.8429978859
453PhosphorylationTKTYNSVSKVDKISR
CCCCCCCCHHHHHHH		27.1229978859
459PhosphorylationVSKVDKISRIIFPVL
CCHHHHHHHHHHHHH		24.1429978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GBRA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBRA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBRA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UD2B7_HUMANUGT2B7physical
21988832
SDCB2_HUMANSDCBP2physical
21988832
GBRA5_HUMANGABRA5physical
28514442
ABCA7_HUMANABCA7physical
28514442
SC11C_HUMANSEC11Cphysical
28514442
TM131_HUMANTMEM131physical
28514442
GLRB_HUMANGLRBphysical
28514442
TUSC3_HUMANTUSC3physical
28514442
AMGO1_HUMANAMIGO1physical
28514442
TM59L_HUMANTMEM59Lphysical
28514442
TTC17_HUMANTTC17physical
28514442
EDA_HUMANEDAphysical
28514442
POMT1_HUMANPOMT1physical
28514442
SPCS1_HUMANSPCS1physical
28514442
WLS_HUMANWLSphysical
28514442
ALG9_HUMANALG9physical
28514442
S47A1_HUMANSLC47A1physical
28514442
1C07_HUMANHLA-Cphysical
28514442
GPAA1_HUMANGPAA1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00058 Gamma-Aminobutyric acid (JAN); Gammalon (TN)
D00225 Alprazolam (JP16/USP/INN); Xanax (TN)
D00267 Chlordiazepoxide (JP16/USP/INN); Libritabs (TN)
D00280 Clonazepam (JP16/USP/INN); Klonopin (TN)
D00293 Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
D00311 Estazolam (JP16/USAN/INN); ProSom (TN)
D00329 Flurazepam (JAN/INN); Insumin (TN)
D00331 Furosemide (JP16/USP/INN); Frusemide; Lasix (TN)
D00365 Lorazepam (JP16/USP/INN); Ativan (TN)
D00370 Temazepam (USP/INN); Restoril (TN)
D00376 Meprobamate (JAN/USP/INN); Equanil (TN); Miltown (TN)
D00387 Triazolam (JAN/USP/INN); Halcion (TN)
D00430 Secobarbital (USP/INN); Seconal (TN)
D00457 Quazepam (JAN/USP/INN); Doral (TN)
D00470 Prazepam (JP16/USAN/INN); Centrax (TN)
D00499 Pentobarbital (USP/INN); Nembutal (TN)
D00500 Pentobarbital sodium (JAN/USP); Nembutal sodium (TN)
D00506 Phenobarbital (JP16/USP/INN); Luminal (TN)
D00531 Nitrazepam (JP16/USAN/INN); Benzalin (TN); Nitrazepam (TN)
D00532 Glutethimide (JAN/INN); Doriden (TN)
D00549 Propofol (JAN/USAN/INN); Diprivan (TN)
D00550 Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN)
D00555 Amobarbital (JP16/INN); Isomytal (TN)
D00557 Methaqualone (JAN/USAN/INN)
D00693 Chlordiazepoxide hydrochloride (JAN/USP); Librium (TN)
D00694 Clorazepate dipotassium (JP16/USP); Tranxene (TN)
D00695 Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN)
D00696 Midazolam hydrochloride (USAN); Versed (TN)
D00697 Flumazenil (JAN/USP/INN); Romazicon (TN)
D00700 Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN)
D00701 Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
D00706 Zolpidem tartrate (JP16/USAN); Ambien (TN); Intermezzo (TN)
D00713 Thiamylal sodium (JP16); Surital (TN)
D00714 Thiopental sodium (JP16/USP/INN); Pentothal (TN)
D01071 Hexobarbital (JAN/INN)
D01230 Flunitrazepam (JP16/USAN/INN); Rohypnol (TN)
D01245 Bromazepam (JP16/USAN/INN); Lectopam (TN)
D01253 Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN)
D01254 Tofisopam (JP16/INN); Emandaxin (TN)
D01268 Cloxazolam (JP16/INN); Sepazon (TN)
D01278 Oxazolam (JP16/INN); Serenal (TN)
D01279 Flutoprazepam (JP16/INN); Restas (TN)
D01286 Flutazolam (JAN/INN); Coreminal (TN)
D01292 Medazepam (JP16/INN); Pamnace (TN)
D01293 Ethyl loflazepate (JAN/INN); Meilax (TN)
D01310 Secobarbital sodium (JAN/USP); Seconal sodium (TN)
D01316 Mexazolam (JAN/INN); Melex (TN)
D01328 Clotiazepam (JP16/INN); Rize (TN)
D01354 Fludiazepam (JP16/INN); Erispan (TN)
D01372 Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN)
D01408 Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN)
D01514 Etizolam (JP16/INN); Sedekopan (TN)
D01564 Rilmazafone hydrochloride hydrate (JAN); Rilmazafone hydrochloride dihydrate; Rilmazafone hydrochlor
D01593 Nimetazepam (JAN/INN); Erimin (TN)
D01657 Lormetazepam (JAN/USAN/INN); Loramet (TN)
D01740 Barbital (JP16/INN); Barbital (TN)
D01744 Brotizolam (JP16/USAN/INN); Lendormin (TN)
D01758 Haloxazolam (JP16/INN); Somelin (TN)
D02252 Amobarbital sodium (JAN/USP); Amytal sodium (TN)
D02253 Pentobarbital calcium (JP16); Ravona (TN)
D02283 Iomazenil (123I) (JAN/INN); Benzodine (TN)
D02594 Abecarnil (INN)
D02616 Pagoclone (USAN/INN); Bextra (TN)
D02617 Ocinaplon (USAN/INN)
D02624 Eszopiclone (JAN/USAN/INN); Estorra (TN); Lunesta (TN)
D02833 Alpidem (USAN/INN)
D03155 Bretazenil (USAN/INN)
D03562 Clorazepate monopotassium (USAN)
D03737 Dextofisopam (USAN/INN)
D04257 Fospropofol disodium (USAN); Aquavan (TN); Lusedra (TN)
D04282 Gaboxadol (USAN/INN)
D04300 Ganaxolone (USAN/INN)
D04721 Levotofisopam (USAN/INN)
D04882 Medazepam hydrochloride (USAN); Nobrium (TN)
D05028 Midazolam maleate (USAN)
D06106 Thiamylal
D07326 Loprazolam (INN); Dormonoct (TN)
D07409 Pentetrazol (INN); Pentylenetetrazol; Coryvet [veterinary] (TN)
D07784 Delorazepam (INN); Dadumir (TN)
D07999 Sodium furosemide; Frosemide sodium; Lasix (TN)
D08001 Furosemide diolamine; Furosemide diethanolamine salt; Nuriban (TN)
D08145 Loprazolam mesilate; Loprazolam mesylate; Loprazolam methanesulfonate; Havlane (TN)
D08283 Nordazepam (INN); Calmday (TN)
D08356 Phenobarbital diethylamine; Gratusminal (TN)
D08481 Rilmazafone (INN)
D08507 Sarmazenil (INN); Sarmazol [veterinary] (TN)
D08690 Zolpidem (INN); Sanval (TN)
D08840 Adipiplon (USAN)
D10194 Remimazolam besilate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBRA3_HUMAN

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Related Literatures of Post-Translational Modification

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