UD2B7_HUMAN - dbPTM
UD2B7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UD2B7_HUMAN
UniProt AC P16662
Protein Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Organism Homo sapiens (Human).
Sequence Length 529
Subcellular Localization Microsome membrane
Single-pass membrane protein . Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.; Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro)..
Protein Sequence MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVKWTSVI
------CCCCHHHHH		32.1924719451
67N-linked_GlycosylationASILFDPNNSSALKI
EEEEECCCCCCCEEE		63.96UniProtKB CARBOHYD
68N-linked_GlycosylationSILFDPNNSSALKIE
EEEECCCCCCCEEEE		42.6119159218
236PhosphorylationMKKWDQFYSEVLGRP
HHHHHHHHHHHHCCC		9.7819289110
315N-linked_GlycosylationSLGSMVSNMTEERAN
ECCHHHCCCCHHHHH		29.95UniProtKB CARBOHYD
430AcetylationTDLLNALKRVINDPS
HHHHHHHHHHHCCHH		42.0612654849
437PhosphorylationKRVINDPSYKENVMK
HHHHCCHHHHHHHHH		52.2629978859
438PhosphorylationRVINDPSYKENVMKL
HHHCCHHHHHHHHHH		27.9219289110
469DimethylationFWIEFVMRHKGAKHL
HHHHHHHHCCCCCCC		24.06-
469MethylationFWIEFVMRHKGAKHL
HHHHHHHHCCCCCCC		24.0618938769
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
438YPhosphorylationKinaseSRCP12931
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UD2B7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UD2B7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CP3A4_HUMANCYP3A4physical
15611481
CP3A4_HUMANCYP3A4physical
15486048
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00195 Codeine (USP); Codeine hydrate
D00413 Zidovudine (JP16/USP/INN); Retrovir (TN)
D02101 Codeine phosphate hydrate (JP16); Codeine phosphate (USP); Codeine (TN)
D03580 Codeine sulfate (USP); Codeine sulfate trihydrate
D07740 Codeine hydrochloride; Bisoltus (TN)
DrugBank
DB01076Atorvastatin
DB00564Carbamazepine
DB06777Chenodeoxycholic acid
DB00318Codeine
DB06695Dabigatran etexilate
DB06292Dapagliflozin
DB00586Diclofenac
DB00445Epirubicin
DB00749Etodolac
DB00973Ezetimibe
DB01544Flunitrazepam
DB00712Flurbiprofen
DB01095Fluvastatin
DB01050Ibuprofen
DB00328Indomethacin
DB00678Losartan
DB00227Lovastatin
DB01252Mitiglinide
DB00295Morphine
DB00688Mycophenolate mofetil
DB01024Mycophenolic acid
DB00788Naproxen
DB00842Oxazepam
DB08860Pitavastatin
DB06207Silodosin
DB00641Simvastatin
DB00870Suprofen
DB06204Tapentadol
DB00313Valproic Acid
DB00495Zidovudine
Regulatory Network of UD2B7_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68, AND MASS SPECTROMETRY.

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