ATTY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATTY_HUMAN
• UniProt AC: P17735
• Protein Name: Tyrosine aminotransferase
• Gene Name: TAT
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Protein Description: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine..
• Protein Sequence: MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPYMIQM -------CCCCEEEC	12.05	-
10	Phosphorylation	PYMIQMSSKGNLPSI CCEEECCCCCCCCCE	38.96	-
33	Acetylation	GRSSVPGKMKGRKAR CCCCCCCCCCCCCCC	31.22	20167786
280	N6-(pyridoxal phosphate)lysine	LSCGGLAKRWLVPGW EECCHHHHHCCCCCC	49.50	-
280	Other	LSCGGLAKRWLVPGW EECCHHHHHCCCCCC	49.50	-
321	Phosphorylation	QRILGPCTIVQGALK HHHHCCCHHHHHHHH	27.58	24670416
344	Phosphorylation	EFYHNTLSFLKSNAD CHHHHHHHHHHHCHH	26.88	24719451
442	Phosphorylation	QEFCEQHYHCAEGSQ HHHHHHHCHHCCCCH	9.78	24275569
448	Phosphorylation	HYHCAEGSQEECDK- HCHHCCCCHHHHCC-	26.39	20166139

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATTY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATTY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATTY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRN_HUMAN	GRN	physical	12588988
ATTY_HUMAN	TAT	physical	25416956
UBE3A_HUMAN	UBE3A	physical	25416956
AASD1_HUMAN	AARSD1	physical	26186194
AASD1_HUMAN	AARSD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 276600: Tyrosinemia 2 (TYRSN2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00120: L-Phenylalanine
• DB00135: L-Tyrosine