TCF19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCF19_HUMAN
• UniProt AC: Q9Y242
• Protein Name: Transcription factor 19
• Gene Name: TCF19
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Subcellular Localization: Nucleus .
• Protein Description: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression..
• Protein Sequence: MLPCFQLLRIGGGRGGDLYTFHPPAGAGCTYRLGHRADLCDVALRPQQEPGLISGIHAELHAEPRGDDWRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGPEGPPGTSPSEFYFMFQQVRVKPQDFAAITIPRSRGEARVGAGFRPMLPSQGAPQRPLSTFSPAPKATLILNSIGSLSKLRPQPLTFSPSWGGPKSLPVPAPPGEMGTTPSAPPQRNRRKSVHRVLAELDDESEPPENPPPVLMEPRKKLRVDKAPLTPTGNRRGRPRKYPVSAPMAPPAVGGGEPCAAPCCCLPQEETVAWVQCDGCDVWFHVACVGCSIQAAREADFRCPGCRAGIQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Methylation	LLRIGGGRGGDLYTF EEEECCCCCCCCEEE	49.55	30761345
19	Phosphorylation	GGRGGDLYTFHPPAG CCCCCCCEEECCCCC	16.46	-
20	Phosphorylation	GRGGDLYTFHPPAGA CCCCCCEEECCCCCC	23.82	-
30	Phosphorylation	PPAGAGCTYRLGHRA CCCCCCCCEECCCCC	15.68	-
31	Phosphorylation	PAGAGCTYRLGHRAD CCCCCCCEECCCCCC	14.12	-
78	Phosphorylation	VSLEDHSSQGTLVNN EEEECCCCCCEEEEC	29.25	17525332
135	Phosphorylation	PQDFAAITIPRSRGE CCCEEEEEEECCCCC	21.87	24719451
138	Methylation	FAAITIPRSRGEARV EEEEEEECCCCCCCC	34.83	115918329
155	Phosphorylation	GFRPMLPSQGAPQRP CCCCCCCCCCCCCCC	36.97	-
181	Phosphorylation	LILNSIGSLSKLRPQ EEECCCCCHHHCCCC	28.00	25627689
183	Phosphorylation	LNSIGSLSKLRPQPL ECCCCCHHHCCCCCC	31.20	25627689
191	Phosphorylation	KLRPQPLTFSPSWGG HCCCCCCCCCCCCCC	28.84	25159151
193	Phosphorylation	RPQPLTFSPSWGGPK CCCCCCCCCCCCCCC	16.88	22199227
195	Phosphorylation	QPLTFSPSWGGPKSL CCCCCCCCCCCCCCC	36.84	29514088
263	Phosphorylation	RVDKAPLTPTGNRRG CCCCCCCCCCCCCCC	20.11	27732954
265	Phosphorylation	DKAPLTPTGNRRGRP CCCCCCCCCCCCCCC	41.68	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCF19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCF19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCF19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR16_HUMAN	NGFR	physical	10485890
LZTR1_HUMAN	LZTR1	physical	20211142
A4_HUMAN	APP	physical	21832049
DNJA3_HUMAN	DNAJA3	physical	25416956
E2F6_HUMAN	E2F6	physical	28514442
MBD3_HUMAN	MBD3	physical	28514442
MTA3_HUMAN	MTA3	physical	28514442
MTA2_HUMAN	MTA2	physical	28514442
LIN9_HUMAN	LIN9	physical	28514442
P66B_HUMAN	GATAD2B	physical	28514442
MTA1_HUMAN	MTA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASSSPECTROMETRY.
PubMed: 17525332