ABTB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABTB1_HUMAN
• UniProt AC: Q969K4
• Protein Name: Ankyrin repeat and BTB/POZ domain-containing protein 1
• Gene Name: ABTB1 {ECO:0000312|HGNC:HGNC:18275}
• Organism: Homo sapiens (Human).
• Sequence Length: 478
• Subcellular Localization: Cytoplasm .
• Protein Description: May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes..
• Protein Sequence: MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTSDLFASC -----CCHHHHHHHH	23.89	29759185
4	Phosphorylation	----MDTSDLFASCR ----CCHHHHHHHHC	28.22	29759185
9	Phosphorylation	DTSDLFASCRKGDVG CHHHHHHHHCCCCHH	13.71	29759185
65	Ubiquitination	NGARCEANTFDGERC CCCCCEECCCCCCCC	20.98	29967540
74	Phosphorylation	FDGERCLYGALSDPI CCCCCCHHHHHCHHH	12.18	7337013
76	Ubiquitination	GERCLYGALSDPIRR CCCCHHHHHCHHHHH	7.13	29967540
88	Phosphorylation	IRRALRDYKQVTASC HHHHHHHHHHHHHHH	9.26	22210691
92	Phosphorylation	LRDYKQVTASCRRRD HHHHHHHHHHHHCCC	15.45	28348404
94	Phosphorylation	DYKQVTASCRRRDYY HHHHHHHHHHCCCCH	9.97	28348404
139	Phosphorylation	VLGARSAYFANMLDT HHCCCHHHHHHCCCC	12.41	113330649
193	Ubiquitination	SDCERLAKQCQLWDL HHHHHHHHHHHHHHH	57.08	-
207	Ubiquitination	LLSDLEAKCEKVSEF HHHHHHHHHHHHHHH	33.29	29967540
218	Ubiquitination	VSEFVASKPGTCVKV HHHHHHCCCCCEEEE	37.42	29967540
264	Ubiquitination	LWELPFPCPDGFNSC CCCCCCCCCCCCCCC	4.99	29967540
268	Ubiquitination	PFPCPDGFNSCPDIC CCCCCCCCCCCCHHH	8.73	29967540
280	Ubiquitination	DICFRVAGCSFLCHK HHHHHHCCCHHHHCH	12.54	29967540
401	Phosphorylation	ARLEDQCTEYMAKVI HCHHHHHHHHHHHHH	25.23	29083192
403	Phosphorylation	LEDQCTEYMAKVIEK HHHHHHHHHHHHHHH	5.57	29083192
406	Ubiquitination	QCTEYMAKVIEKLVE HHHHHHHHHHHHHHH	27.50	29967540
410	Ubiquitination	YMAKVIEKLVEREDF HHHHHHHHHHHCHHH	46.86	29967540
422	Ubiquitination	EDFVEAVKEEAAAVA HHHHHHHHHHHHHHH	57.81	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABTB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABTB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABTB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TDIF1_HUMAN	DNTTIP1	physical	19930467
ZBT21_HUMAN	ZBTB21	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
SYCC_HUMAN	CARS	physical	28514442
EF1D_HUMAN	EEF1D	physical	28514442
SYVC_HUMAN	VARS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.