RAB38_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB38_MOUSE
• UniProt AC: Q8QZZ8
• Protein Name: Ras-related protein Rab-38
• Gene Name: Rab38
• Organism: Mus musculus (Mouse).
• Sequence Length: 211
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Melanosome membrane . Recruited to phagosomes containing S.aureus or M.tubercu
• Protein Description: Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. [PubMed: 21187289 Plays an important role in the control of melanin production and melanosome biogenesis (By similarity In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes]
• Protein Sequence: MQTPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLTLPNGKPVSVVLLANKCDQGKDVLMNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDLLESIEPDIVKPHLTSPKVVSCSGCAKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	NECDLLESIEPDIVK CCCCHHHHCCCCCCC	32.02	28978645
198	Phosphorylation	DIVKPHLTSPKVVSC CCCCCCCCCCCEEEC	39.69	30482847
205	S-palmitoylation	TSPKVVSCSGCAKS- CCCCEEECCCCCCC-	2.47	-
208	Geranylgeranylation	KVVSCSGCAKS---- CEEECCCCCCC----	2.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB38_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB38_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB38_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB38_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.