SARG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SARG_HUMAN
• UniProt AC: Q9BW04
• Protein Name: Specifically androgen-regulated gene protein
• Gene Name: SARG
• Organism: Homo sapiens (Human).
• Sequence Length: 601
• Subcellular Localization: Cytoplasm .
• Protein Description: Putative androgen-specific receptor..
• Protein Sequence: MPERELWPAGTGSEPVTRVGSCDSMMSSTSTRSGSSDSSYDFLSTEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRGFRALPITQPTPRGGPEETITQQGRTPRTVTESSSSHPPEPQGLGLRSGSYSLPRNIHIARSQNFRKSTTQASSHNPGEPGRLAPEPEKEQVSQSSQPRQAPASPQEAALDLDVVLIPPPEAFRDTQPEQCREASLPEGPGQQGHTPQLHTPSSSQEREQTPSEAMSQKAKETVSTRYTQPQPPPAGLPQNARAEDAPLSSGEDPNSRLAPLTTPKPRKLPPNIVLKSSRSSFHSDPQHWLSRHTEAAPGDSGLISCSLQEQRKARKEALEKLGLPQDQDEPGLHLSKPTSSIRPKETRAQHLSPAPGLAQPAAPAQASAAIPAAGKALAQAPAPAPGPAQGPLPMKSPAPGNVAASKSMPISIPKAPRANSALTPPKPESGLTLQESNTPGLRQMNFKSNTLERSGVGLSSYLSTEKDASPKTSTSLGKGSFLDKISPSVLRNSRPRPASLGTGKDFAGIQVGKLADLEQEQSSKRLSYQGQSRDKLPRPPCVSVKISPKGVPNEHRREALKKLGLLKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	EPVTRVGSCDSMMSS CCCCEEECCCCCCCC	16.34	25106551
24	Phosphorylation	TRVGSCDSMMSSTST CEEECCCCCCCCCCC	22.25	27251275
27	Phosphorylation	GSCDSMMSSTSTRSG ECCCCCCCCCCCCCC	23.09	27251275
28	Phosphorylation	SCDSMMSSTSTRSGS CCCCCCCCCCCCCCC	14.42	27251275
29	Phosphorylation	CDSMMSSTSTRSGSS CCCCCCCCCCCCCCC	27.15	27251275
30	Phosphorylation	DSMMSSTSTRSGSSD CCCCCCCCCCCCCCC	24.62	26853621
31	Phosphorylation	SMMSSTSTRSGSSDS CCCCCCCCCCCCCCC	29.01	27251275
33	Phosphorylation	MSSTSTRSGSSDSSY CCCCCCCCCCCCCCC	43.02	24702127
35	Phosphorylation	STSTRSGSSDSSYDF CCCCCCCCCCCCCCC	32.02	26657352
36	Phosphorylation	TSTRSGSSDSSYDFL CCCCCCCCCCCCCCC	45.07	26657352
38	Phosphorylation	TRSGSSDSSYDFLST CCCCCCCCCCCCCCH	32.52	24702127
39	Phosphorylation	RSGSSDSSYDFLSTE CCCCCCCCCCCCCHH	33.44	23927012
40	Phosphorylation	SGSSDSSYDFLSTEE CCCCCCCCCCCCHHH	18.05	24702127
60	Phosphorylation	FLEETIGSLDTEADS HHHHHHCCCCCCCCC	21.15	28348404
63	Phosphorylation	ETIGSLDTEADSGLS HHHCCCCCCCCCCCC	38.06	28348404
67	Phosphorylation	SLDTEADSGLSTDES CCCCCCCCCCCCCCC	48.99	28348404
70	Phosphorylation	TEADSGLSTDESEPA CCCCCCCCCCCCCCC	37.02	28348404
71	Phosphorylation	EADSGLSTDESEPAT CCCCCCCCCCCCCCC	49.15	28348404
78	Phosphorylation	TDESEPATTPRGFRA CCCCCCCCCCCCEEE	48.31	28348404
79	Phosphorylation	DESEPATTPRGFRAL CCCCCCCCCCCEEEC	17.07	28348404
89	Phosphorylation	GFRALPITQPTPRGG CEEECCCCCCCCCCC	26.93	24719451
92	Phosphorylation	ALPITQPTPRGGPEE ECCCCCCCCCCCCCH	18.79	27794612
107	Phosphorylation	TITQQGRTPRTVTES HHCCCCCCCCEECCC	24.77	24719451
129	Phosphorylation	PQGLGLRSGSYSLPR CCCCCCCCCCCCCCC	36.81	26657352
131	Phosphorylation	GLGLRSGSYSLPRNI CCCCCCCCCCCCCCE	16.88	28355574
132	Phosphorylation	LGLRSGSYSLPRNIH CCCCCCCCCCCCCEE	20.11	24702127
133	Phosphorylation	GLRSGSYSLPRNIHI CCCCCCCCCCCCEEE	33.33	28355574
143	Phosphorylation	RNIHIARSQNFRKST CCEEEECCCCCHHCC	22.06	23312004
149	Phosphorylation	RSQNFRKSTTQASSH CCCCCHHCCCCHHHC	32.22	22617229
150	Phosphorylation	SQNFRKSTTQASSHN CCCCHHCCCCHHHCC	26.43	22617229
151	Phosphorylation	QNFRKSTTQASSHNP CCCHHCCCCHHHCCC	29.27	26657352
154	Phosphorylation	RKSTTQASSHNPGEP HHCCCCHHHCCCCCC	23.47	25394399
155	Phosphorylation	KSTTQASSHNPGEPG HCCCCHHHCCCCCCC	30.24	23090842
174	Phosphorylation	EPEKEQVSQSSQPRQ CCHHHHCCCCCCCCC	24.84	28985074
185	Phosphorylation	QPRQAPASPQEAALD CCCCCCCCHHHHHHC	26.51	26657352
216	Phosphorylation	PEQCREASLPEGPGQ HHHHHHCCCCCCCCC	39.44	18510355
227	Phosphorylation	GPGQQGHTPQLHTPS CCCCCCCCCCCCCCC	21.39	18510355
232	Phosphorylation	GHTPQLHTPSSSQER CCCCCCCCCCCHHHH	33.20	18510355
234	Phosphorylation	TPQLHTPSSSQEREQ CCCCCCCCCHHHHCC	43.72	24400094
235	Phosphorylation	PQLHTPSSSQEREQT CCCCCCCCHHHHCCC	36.93	24400094
248	Phosphorylation	QTPSEAMSQKAKETV CCHHHHHHHHHHHHH	35.26	25954137
254	Phosphorylation	MSQKAKETVSTRYTQ HHHHHHHHHHHCCCC	21.03	25954137
256	Phosphorylation	QKAKETVSTRYTQPQ HHHHHHHHHCCCCCC	18.00	25954137
257	Phosphorylation	KAKETVSTRYTQPQP HHHHHHHHCCCCCCC	24.29	25954137
259	Phosphorylation	KETVSTRYTQPQPPP HHHHHHCCCCCCCCC	15.15	28152594
260	Phosphorylation	ETVSTRYTQPQPPPA HHHHHCCCCCCCCCC	30.40	25394399
281	Phosphorylation	RAEDAPLSSGEDPNS CHHHCCCCCCCCCCC	34.93	25394399
282	Phosphorylation	AEDAPLSSGEDPNSR HHHCCCCCCCCCCCC	54.61	22617229
294	Phosphorylation	NSRLAPLTTPKPRKL CCCCCCCCCCCCCCC	39.74	23090842
295	Phosphorylation	SRLAPLTTPKPRKLP CCCCCCCCCCCCCCC	36.68	23090842
308	Methylation	LPPNIVLKSSRSSFH CCCCEEEECCCCCCC	35.18	83364269
309	Phosphorylation	PPNIVLKSSRSSFHS CCCEEEECCCCCCCC	27.16	23312004
310	Phosphorylation	PNIVLKSSRSSFHSD CCEEEECCCCCCCCC	34.30	23312004
312	Phosphorylation	IVLKSSRSSFHSDPQ EEEECCCCCCCCCHH	39.03	26657352
313	Phosphorylation	VLKSSRSSFHSDPQH EEECCCCCCCCCHHH	26.35	25159151
316	Phosphorylation	SSRSSFHSDPQHWLS CCCCCCCCCHHHHHH	49.31	29496963
323	Phosphorylation	SDPQHWLSRHTEAAP CCHHHHHHHCCCCCC	19.47	23312004
337	Phosphorylation	PGDSGLISCSLQEQR CCCCCCHHCCHHHHH	11.60	28348404
339	Phosphorylation	DSGLISCSLQEQRKA CCCCHHCCHHHHHHH	26.71	28348404
385	Phosphorylation	ETRAQHLSPAPGLAQ CHHCHHCCCCCCCCC	19.52	25159151
400	Phosphorylation	PAAPAQASAAIPAAG CCCHHHHHHHHCHHH	13.22	27251275
428	Methylation	AQGPLPMKSPAPGNV CCCCCCCCCCCCCCC	51.88	115977531
429	Phosphorylation	QGPLPMKSPAPGNVA CCCCCCCCCCCCCCC	21.75	26657352
438	Phosphorylation	APGNVAASKSMPISI CCCCCCCCCCCCCCC	18.61	23090842
440	Phosphorylation	GNVAASKSMPISIPK CCCCCCCCCCCCCCC	27.56	27251275
453	Phosphorylation	PKAPRANSALTPPKP CCCCCCCCCCCCCCC	24.54	30266825
456	Phosphorylation	PRANSALTPPKPESG CCCCCCCCCCCCCCC	36.94	30266825
462	Phosphorylation	LTPPKPESGLTLQES CCCCCCCCCCCCCCC	47.86	23927012
465	Phosphorylation	PKPESGLTLQESNTP CCCCCCCCCCCCCCC	29.89	23927012
469	Phosphorylation	SGLTLQESNTPGLRQ CCCCCCCCCCCCHHH	32.80	23927012
471	Phosphorylation	LTLQESNTPGLRQMN CCCCCCCCCCHHHCC	28.19	23927012
480	Methylation	GLRQMNFKSNTLERS CHHHCCCCCCCCCCC	37.48	81424269
481	Phosphorylation	LRQMNFKSNTLERSG HHHCCCCCCCCCCCC	30.80	23090842
483	Phosphorylation	QMNFKSNTLERSGVG HCCCCCCCCCCCCCC	36.77	28985074
487	Phosphorylation	KSNTLERSGVGLSSY CCCCCCCCCCCHHHH	28.58	23090842
492	Phosphorylation	ERSGVGLSSYLSTEK CCCCCCHHHHHCCCC	15.82	23090842
493	Phosphorylation	RSGVGLSSYLSTEKD CCCCCHHHHHCCCCC	34.83	23090842
494	Phosphorylation	SGVGLSSYLSTEKDA CCCCHHHHHCCCCCC	10.99	27259358
496	Phosphorylation	VGLSSYLSTEKDASP CCHHHHHCCCCCCCC	26.70	25159151
497	Phosphorylation	GLSSYLSTEKDASPK CHHHHHCCCCCCCCC	44.45	25159151
502	Phosphorylation	LSTEKDASPKTSTSL HCCCCCCCCCCCCCC	36.74	22617229
504	Methylation	TEKDASPKTSTSLGK CCCCCCCCCCCCCCC	53.24	115977539
505	Phosphorylation	EKDASPKTSTSLGKG CCCCCCCCCCCCCCC	40.39	25219547
506	Phosphorylation	KDASPKTSTSLGKGS CCCCCCCCCCCCCCC	23.33	25219547
507	Phosphorylation	DASPKTSTSLGKGSF CCCCCCCCCCCCCCH	32.95	25219547
508	Phosphorylation	ASPKTSTSLGKGSFL CCCCCCCCCCCCCHH	34.59	25394399
511	Methylation	KTSTSLGKGSFLDKI CCCCCCCCCCHHHHC	57.59	100328853
513	Phosphorylation	STSLGKGSFLDKISP CCCCCCCCHHHHCCH	26.56	23927012
519	Phosphorylation	GSFLDKISPSVLRNS CCHHHHCCHHHHHCC	19.50	28355574
521	Phosphorylation	FLDKISPSVLRNSRP HHHHCCHHHHHCCCC	27.30	23927012
526	Phosphorylation	SPSVLRNSRPRPASL CHHHHHCCCCCCCCC	36.91	27542207
532	Phosphorylation	NSRPRPASLGTGKDF CCCCCCCCCCCCCCC	29.98	23927012
535	Phosphorylation	PRPASLGTGKDFAGI CCCCCCCCCCCCCCC	46.48	27987026
555	Phosphorylation	ADLEQEQSSKRLSYQ CHHHHHHHHCCCCCC	36.75	27251275
560	Phosphorylation	EQSSKRLSYQGQSRD HHHHCCCCCCCCCCC	21.31	25159151
561	Phosphorylation	QSSKRLSYQGQSRDK HHHCCCCCCCCCCCC	22.66	28152594
565	Phosphorylation	RLSYQGQSRDKLPRP CCCCCCCCCCCCCCC	49.63	23312004
576	Phosphorylation	LPRPPCVSVKISPKG CCCCCEEEEECCCCC	25.14	23312004
580	Phosphorylation	PCVSVKISPKGVPNE CEEEEECCCCCCCHH	18.16	25056879

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SARG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SARG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SARG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOME1_HUMAN	HOMER1	physical	19447967
HOME1_HUMAN	HOMER1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.