NUAK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUAK2_MOUSE
• UniProt AC: Q8BZN4
• Protein Name: NUAK family SNF1-like kinase 2
• Gene Name: Nuak2 {ECO:0000312|MGI:MGI:1921387}
• Organism: Mus musculus (Mouse).
• Sequence Length: 639
• Protein Description: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity)..
• Protein Sequence: MESVALLQRPSQAPSASALASESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGEQEALREGGHPSGDFGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTVPGLERQHSLKKSRKENDMAQNLQGDPAEDTSSRPGKSSLKLPKGILKKKSSTSSGEVQEDPQELRPVPDTPGQPVPAVSLLPRKGILKKSRQRESGYYSSPEPSESGELLDASDVFVSGDPVEQKSPQASGLLLHRKGILKLNGKFSRTALEGTTPSTFGSLDQLASSHPAARPSRPSGAVSEDSILSSESFDQLDLPERLPETPLRGCVSVDNLRGLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESVALLQ -------CCCCCCCC	8.59	-
11	Phosphorylation	VALLQRPSQAPSASA CCCCCCCCCCCCHHH	40.96	24719451
46	Methylation	MKKQAVKRHHHKHNL HCHHHHHHHHHHHCH	27.98	16288511
150	Phosphorylation	YASRGDLYDYISERP ECCCCCHHHHHHCCC	16.08	-
154	Phosphorylation	GDLYDYISERPRLSE CCHHHHHHCCCCCCH	22.71	-
220	Phosphorylation	HKGKFLQTFCGSPLY CCCCCHHHHCCCCCC	24.04	-
407	Phosphorylation	QGDPAEDTSSRPGKS CCCCCCCCCCCCCCC	21.80	30635358
408	Phosphorylation	GDPAEDTSSRPGKSS CCCCCCCCCCCCCCC	36.35	30635358
409	Phosphorylation	DPAEDTSSRPGKSSL CCCCCCCCCCCCCCC	44.58	30635358
414	Phosphorylation	TSSRPGKSSLKLPKG CCCCCCCCCCCCCCC	46.98	30635358
415	Phosphorylation	SSRPGKSSLKLPKGI CCCCCCCCCCCCCCC	32.77	30635358
503	Phosphorylation	GDPVEQKSPQASGLL CCCCCCCCCCCCCEE	23.18	29472430
507	Phosphorylation	EQKSPQASGLLLHRK CCCCCCCCCEEECCC	25.40	20531401
538	Phosphorylation	TTPSTFGSLDQLASS CCCCCCCCHHHHHHC	25.28	-
559	Phosphorylation	SRPSGAVSEDSILSS CCCCCCCCCCCCCCC	34.84	-
562	Phosphorylation	SGAVSEDSILSSESF CCCCCCCCCCCCCCC	22.75	-
588	Phosphorylation	TPLRGCVSVDNLRGL CCCCCCEECCCCCCC	28.03	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUAK2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
220	T	Phosphorylation	Phosphorylated at Thr-220 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUAK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NUAK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.