RGS3_MOUSE - dbPTM
RGS3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGS3_MOUSE
UniProt AC Q9DC04
Protein Name Regulator of G-protein signaling 3
Gene Name Rgs3
Organism Mus musculus (Mouse).
Sequence Length 966
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.
Isoform 2: Cytoplasm .
Isoform 3: Nucleus .
Isoform 4: Nucleus .
Protein Description Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases..
Protein Sequence MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGPDGGVLRRASCKSTHDLLSPPNKREKNCTHGAPVRPEQRHSCHLVCDSSDGLLLGGWERYTEVGKRSGQHTLPALSRTTTPTDPNYIILAPLNPGSQLLRPVYQEDTIPEEPGTTTKGKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAAPPTERKMFETEADEKEMPLVEGKGPGAEEPAPSKNPSPGQELPPGQDLPPSKDPSPSQELPAGQDLPPSKDPSPSQELPAGQDLPPSKDPSPSQELPVGQDLPPRKDSSGQEAAPGPESPSSEDIATCPKPPQSPETSTSKDSPPGQGSSPTTELPSCQGLPAGQESTSQDPLLSQEPPVIPESSASVQKRLPSQESPSSLGSLPEKDLAEQTISSGEPPVATGAVLPASRPNFVIPEVRLDNAYSQLDGAHGGSSGEDEDAEEGEEGGEGEEDEEDDTSDDNYGDRSEAKRSSLIETGQGAEGGFSLRVQNSLRRRTHSEGSLLQESRGPCFASDTTLHCSDGEGATSTWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLTECDEASRKRKSKNIAKDMKNKLAIFRRRNESPGAQPASKTDKTTKSFKPTSEEALKWSESLEKLLLHKYGLEVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTREHTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
114PhosphorylationLRRASCKSTHDLLSP
EECCCCCCCCCCCCC		34.9927841257
120PhosphorylationKSTHDLLSPPNKREK
CCCCCCCCCCCCCCC		45.6827841257
167MethylationRYTEVGKRSGQHTLP
ECCCHHHHCCCCCCC		39.84-
215PhosphorylationTIPEEPGTTTKGKSY
CCCCCCCCCCCCCCC		41.84-
216PhosphorylationIPEEPGTTTKGKSYT
CCCCCCCCCCCCCCC		32.21-
217PhosphorylationPEEPGTTTKGKSYTG
CCCCCCCCCCCCCCC		37.32-
395PhosphorylationQQLAAPPTERKMFET
HHHCCCCCHHHCCCC		47.5722802335
429PhosphorylationPAPSKNPSPGQELPP
CCCCCCCCCCCCCCC		51.5628285833
449PhosphorylationPSKDPSPSQELPAGQ
CCCCCCCCCCCCCCC		40.3925521595
461PhosphorylationAGQDLPPSKDPSPSQ
CCCCCCCCCCCCCCC		47.9925521595
467PhosphorylationPSKDPSPSQELPAGQ
CCCCCCCCCCCCCCC		40.3925521595
479PhosphorylationAGQDLPPSKDPSPSQ
CCCCCCCCCCCCCCC		47.9925521595
500PhosphorylationDLPPRKDSSGQEAAP
CCCCCCCCCCCCCCC		39.1319060867
501PhosphorylationLPPRKDSSGQEAAPG
CCCCCCCCCCCCCCC		55.4119060867
511PhosphorylationEAAPGPESPSSEDIA
CCCCCCCCCCHHHHC		32.9625521595
513PhosphorylationAPGPESPSSEDIATC
CCCCCCCCHHHHCCC		56.4925293948
514PhosphorylationPGPESPSSEDIATCP
CCCCCCCHHHHCCCC		42.5525293948
519PhosphorylationPSSEDIATCPKPPQS
CCHHHHCCCCCCCCC		29.6725293948
526PhosphorylationTCPKPPQSPETSTSK
CCCCCCCCCCCCCCC		30.4023375375
529PhosphorylationKPPQSPETSTSKDSP
CCCCCCCCCCCCCCC		40.4625293948
530PhosphorylationPPQSPETSTSKDSPP
CCCCCCCCCCCCCCC		29.0825293948
531PhosphorylationPQSPETSTSKDSPPG
CCCCCCCCCCCCCCC		47.4125293948
532PhosphorylationQSPETSTSKDSPPGQ
CCCCCCCCCCCCCCC		33.9425293948
586PhosphorylationSVQKRLPSQESPSSL
HHHHHCCCCCCCCCC		51.6925266776
589PhosphorylationKRLPSQESPSSLGSL
HHCCCCCCCCCCCCC		23.5725521595
591PhosphorylationLPSQESPSSLGSLPE
CCCCCCCCCCCCCCH		47.6925266776
592PhosphorylationPSQESPSSLGSLPEK
CCCCCCCCCCCCCHH		39.8828066266
595PhosphorylationESPSSLGSLPEKDLA
CCCCCCCCCCHHHHH		46.1521183079
685PhosphorylationDRSEAKRSSLIETGQ
CHHHHHHHHHHHCCC		28.8721082442
686PhosphorylationRSEAKRSSLIETGQG
HHHHHHHHHHHCCCC		37.0825521595
690PhosphorylationKRSSLIETGQGAEGG
HHHHHHHCCCCCCCC		28.0128833060
705PhosphorylationFSLRVQNSLRRRTHS
EEEEECCCHHCCCCC		13.2329472430
710PhosphorylationQNSLRRRTHSEGSLL
CCCHHCCCCCCCCCC		28.1328833060
712PhosphorylationSLRRRTHSEGSLLQE
CHHCCCCCCCCCCHH		42.9425521595
715PhosphorylationRRTHSEGSLLQESRG
CCCCCCCCCCHHCCC		23.1225521595
720PhosphorylationEGSLLQESRGPCFAS
CCCCCHHCCCCCEEE		29.5828833060
727PhosphorylationSRGPCFASDTTLHCS
CCCCCEEECCEEEEC		18.4225266776
729PhosphorylationGPCFASDTTLHCSDG
CCCEEECCEEEECCC		28.8519060867
730PhosphorylationPCFASDTTLHCSDGE
CCEEECCEEEECCCC		21.3525293948
734PhosphorylationSDTTLHCSDGEGATS
ECCEEEECCCCCCCC		37.5925266776
740PhosphorylationCSDGEGATSTWAIPS
ECCCCCCCCCCCCCC		37.2325293948
741PhosphorylationSDGEGATSTWAIPSP
CCCCCCCCCCCCCCC		22.7825293948
742PhosphorylationDGEGATSTWAIPSPR
CCCCCCCCCCCCCCC		17.9825293948
747PhosphorylationTSTWAIPSPRTLKKE
CCCCCCCCCCHHHHH		22.3919060867
761PhosphorylationELGRNGGSMHHLSLF
HHCCCCCCCEEEEEE		19.1525266776
776PhosphorylationFTGHRKMSGTDLTEC
ECCCCCCCCCCCHHH		41.3926824392
778PhosphorylationGHRKMSGTDLTECDE
CCCCCCCCCCHHHHH		22.1128833060
781PhosphorylationKMSGTDLTECDEASR
CCCCCCCHHHHHHHH		37.0628833060
812PhosphorylationIFRRRNESPGAQPAS
HHHHCCCCCCCCCCC		31.9825266776
819PhosphorylationSPGAQPASKTDKTTK
CCCCCCCCCCCCCCC		42.6525266776
820AcetylationPGAQPASKTDKTTKS
CCCCCCCCCCCCCCC		63.9519849315
829AcetylationDKTTKSFKPTSEEAL
CCCCCCCCCCHHHHH		55.2519849327
837AcetylationPTSEEALKWSESLEK
CCHHHHHHHHHHHHH		56.5819849339
933AcetylationGCFDLAQKRIFGLME
HHHHHHHHHHHCHHC		41.6815613487
963PhosphorylationLINQKKMSPPL----
HHHHCCCCCCC----		32.0421183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGS3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGS3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGS3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RGS3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGS3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-712 AND SER-715, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-712 AND SER-715, ANDMASS SPECTROMETRY.

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