dbPTM

T7L1A_DANRE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	T7L1A_DANRE
UniProt AC	Q9YHE8
Protein Name	Transcription factor 7-like 1-A
Gene Name	tcf7l1a
Organism	Danio rerio (Zebrafish) (Brachydanio rerio).
Sequence Length	560
Subcellular Localization	Nucleus .
Protein Description	Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates..
Protein Sequence	MPQLNGGGGDDLGANDELISFKDEGEQEEKISENVSSERDLDEVKSSLVNESENNSSSSDSEQTDRRPRPRPDLESYEKQREYFAEALRRQQDGGFFKGPPYAGYPFLMIPDITNPYLSNGSLSPSTRTYLQMKWPLLDVPASAALKDSRSPTPGHLSNKVPVVQHPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDPKTGIPRTPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQHMYSIPPGGFRHPYPALAMNASMSSLVSSRFSPHMVPHPPHGLHQTGIPHPAIVSPAIKQEPNGESPSNSTHGKPSVPVKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRKRDCKSDSPSESNFSPQPKKQCVPYLSSEKMCDSPTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEGRAHHNHPHFPLPGKSSGSGSGSSMALHSLSRPIPFTSLPPSLLGPNSPFHQAALHSHHALLQTQPLSLVTKSVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of T7L1A_DANRE !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of T7L1A_DANRE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of T7L1A_DANRE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of T7L1A_DANRE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TLE3_HUMAN	TLE3	physical	21666599
HDAC1_HUMAN	HDAC1	physical	21666599

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of T7L1A_DANRE

Related Literatures of Post-Translational Modification