FEZF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEZF2_HUMAN
• UniProt AC: Q8TBJ5
• Protein Name: Fez family zinc finger protein 2
• Gene Name: FEZF2
• Organism: Homo sapiens (Human).
• Sequence Length: 459
• Subcellular Localization: Nucleus.
• Protein Description: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity)..
• Protein Sequence: MASSASLETMVPPACPRAGASPATSKTLAFSIERIMAKTSEPRAPFEPRPGALEADGSQGKKLLNLCSPLPCMIPLQPLGYEVPSKTLLSYSELWKSSLRAGGGGGGGGGGGGGGGGAPVCGASGLCKTNCGVCCKAELGLAPSALPAGRVIKPQVINQAVGLPASGSLYYFNYLDSTAYPPSELLSGHLFPSGLLNAQAPAALAAHPKLFLLENAKLAGLAADKFPHPAPYPHKERLPAPLEQVLKENSALTAERGGVKGHSKLPGGSADGKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCTICNKAFHQVYNLTFHMHTHNDKKPFTCATCGKGFCRNFDLKKHVRKLHDSVGPAAPSAKDLTRTVQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	ASPATSKTLAFSIER CCCCCCHHHHHHHHH	24.08	-
31	Phosphorylation	TSKTLAFSIERIMAK CCHHHHHHHHHHHHH	20.24	-
269	Phosphorylation	HSKLPGGSADGKPKN CCCCCCCCCCCCCCC	29.15	29116813
328	Phosphorylation	CRHKIIHTQEKPHKC HHCCCCCCCCCCCCC	28.19	-
418	Phosphorylation	HNDKKPFTCATCGKG CCCCCCEEECCCCCC	15.12	23403867
421	Phosphorylation	KKPFTCATCGKGFCR CCCEEECCCCCCHHH	24.76	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEZF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEZF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEZF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	23677067

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.