NACC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NACC2_HUMAN
• UniProt AC: Q96BF6
• Protein Name: Nucleus accumbens-associated protein 2
• Gene Name: NACC2
• Organism: Homo sapiens (Human).
• Sequence Length: 587
• Subcellular Localization: Nucleus . Predominantly associated with chromatin.
• Protein Description: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53..
• Protein Sequence: MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPLLTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRTVMGSAAASVPLDPEFPPAAAQVFEQRIYAERRGDAATIVALRTDAVNVDLSAAANPAFDAGEEVDGAGSVIQEVAAPEPLPADGQSPPQPFEQGGGGPSRPQTPAAAARRPEGTYAGTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	EQRLLGLYCDVSIVV HHHHHHEECCEEEEE	5.70	-
33	Phosphorylation	LGLYCDVSIVVKGQA HHEECCEEEEECCCH	9.09	-
124	Phosphorylation	TDLMFKVSSPHCDSQ CCEEEEECCCCCCCC	38.45	28348404
125	Phosphorylation	DLMFKVSSPHCDSQT CEEEEECCCCCCCCE	22.96	28348404
130	Phosphorylation	VSSPHCDSQTAVIED ECCCCCCCCEEEEEC	34.52	28348404
132	Phosphorylation	SPHCDSQTAVIEDAG CCCCCCCEEEEECCC	27.18	28348404
140	Phosphorylation	AVIEDAGSEPQSPCN EEEECCCCCCCCCHH	48.07	28348404
144	Phosphorylation	DAGSEPQSPCNQLQP CCCCCCCCCHHHHCH	41.98	28348404
174	Sumoylation	IPLLTRVKHEAMELP CCCEEECCCHHHCCC	32.22	28112733
174	Sumoylation	IPLLTRVKHEAMELP CCCEEECCCHHHCCC	32.22	-
217	Sumoylation	AAGTAPLKLPRVSYY HCCCCCCCCCCCEEC	56.22	28112733
223	Phosphorylation	LKLPRVSYYGVPSLA CCCCCCEECCCCCHH	11.03	-
224	Phosphorylation	KLPRVSYYGVPSLAT CCCCCEECCCCCHHH	12.25	-
228	Phosphorylation	VSYYGVPSLATLIPG CEECCCCCHHHHCCC	28.38	-
299	Ubiquitination	GSYAVQEKPEPVPLE CCEECCCCCCCCCCC	37.27	21906983
299	Sumoylation	GSYAVQEKPEPVPLE CCEECCCCCCCCCCC	37.27	-
299	Sumoylation	GSYAVQEKPEPVPLE CCEECCCCCCCCCCC	37.27	28112733
323	Phosphorylation	DLVALPASLISQIGY CHHHCCHHHHHHHCC	25.05	-
388	Phosphorylation	ATFFDRNTLANSCGT HHHHCCCHHHHHCCC	28.30	-
395	Phosphorylation	TLANSCGTGIRSSTS HHHHHCCCCCCCCCC	33.49	28555341
429	Sumoylation	QNFAPSFKESEMNVI HHCCCCCCHHHHHHH	65.74	28112733
456	Sumoylation	KRWLPKIKSMLPEGV HHHHHHHHHHCCCCH	35.62	28112733
456	Ubiquitination	KRWLPKIKSMLPEGV HHHHHHHHHHCCCCH	35.62	21906983
456	Sumoylation	KRWLPKIKSMLPEGV HHHHHHHHHHCCCCH	35.62	-
505	Phosphorylation	ERRGDAATIVALRTD HHHCCCEEEEEEECC	20.08	-
554	Phosphorylation	PLPADGQSPPQPFEQ CCCCCCCCCCCCCCC	44.04	24275569
567	Phosphorylation	EQGGGGPSRPQTPAA CCCCCCCCCCCCHHH	60.92	21552520
571	Phosphorylation	GGPSRPQTPAAAARR CCCCCCCCHHHHHCC	19.99	24719451
583	Phosphorylation	ARRPEGTYAGTL--- HCCCCCCCCCCC---	17.56	24719451
586	Phosphorylation	PEGTYAGTL------ CCCCCCCCC------	22.56	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NACC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NACC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NACC2_HUMAN	NACC2	physical	22926524
HDAC1_HUMAN	HDAC1	physical	22926524
HDAC2_HUMAN	HDAC2	physical	22926524
MTA1_HUMAN	MTA1	physical	22926524
MTA2_HUMAN	MTA2	physical	22926524
RBBP7_HUMAN	RBBP7	physical	22926524
RBBP4_HUMAN	RBBP4	physical	22926524
CHD4_HUMAN	CHD4	physical	22926524
MTA3_HUMAN	MTA3	physical	22926524

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.