| UniProt ID | MTF1_HUMAN | |
|---|---|---|
| UniProt AC | Q14872 | |
| Protein Name | Metal regulatory transcription factor 1 | |
| Gene Name | MTF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 753 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).. | |
| Protein Sequence | MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDEDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNHSLCLSDLSLLSTDSELRENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLPLVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSSCEQSRQAETPSDPQTETLSAMDVSEFLSLQSLDTPSNLIPIEALLQGEEEMGLTSSFSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MGEHSPDNN ------CCCCCCCCC | 41.13 | - | |
| 5 | Phosphorylation | ---MGEHSPDNNIIY ---CCCCCCCCCEEE | 29.64 | 25159151 | |
| 12 | Phosphorylation | SPDNNIIYFEAEEDE CCCCCEEEEEECCCC | 7.50 | 28450419 | |
| 39 | Phosphorylation | KNGLVPSSSGTVYDR CCCCCCCCCCCEEEC | 27.07 | - | |
| 122 | Phosphorylation | PRNIEGATLTLQSEC CCCCCCCEEEEECCC | 31.00 | 25072903 | |
| 124 | Phosphorylation | NIEGATLTLQSECPE CCCCCEEEEECCCCC | 20.56 | 25072903 | |
| 127 | Phosphorylation | GATLTLQSECPETKR CCEEEEECCCCCCCH | 44.25 | 25072903 | |
| 132 | Phosphorylation | LQSECPETKRKEVKR EECCCCCCCHHHCEE | 22.69 | 25072903 | |
| 133 | Ubiquitination | QSECPETKRKEVKRY ECCCCCCCHHHCEEE | 60.86 | 29967540 | |
| 140 | Phosphorylation | KRKEVKRYQCTFEGC CHHHCEEEEECCCCC | 11.39 | 22817900 | |
| 152 | Phosphorylation | EGCPRTYSTAGNLRT CCCCCCCCCCCCEEE | 15.92 | 24719451 | |
| 186 | Phosphorylation | KAFLTSYSLRIHVRV EEEEEEEEEEEEEEE | 15.78 | 24719451 | |
| 215 | Phosphorylation | EKAFNTLYRLKAHQR HHHHHHHHHHHHHHH | 16.32 | 22817900 | |
| 227 | Acetylation | HQRLHTGKTFNCESE HHHCCCCCCEECCCC | 51.61 | 26051181 | |
| 244 | Phosphorylation | SKYFTTLSDLRKHIR HHHEECHHHHHHHHH | 32.29 | 24719451 | |
| 252 | Phosphorylation | DLRKHIRTHTGEKPF HHHHHHHHCCCCCCE | 24.16 | - | |
| 254 | Phosphorylation | RKHIRTHTGEKPFRC HHHHHHCCCCCCEEC | 46.56 | 29496963 | |
| 257 | Ubiquitination | IRTHTGEKPFRCDHD HHHCCCCCCEECCCC | 51.29 | - | |
| 277 | Ubiquitination | FAASHHLKTHVRTHT HHHHHHHHCEEECCC | 32.03 | 29967540 | |
| 284 | Phosphorylation | KTHVRTHTGERPFFC HCEEECCCCCCCEEC | 39.87 | 25159151 | |
| 293 | Phosphorylation | ERPFFCPSNGCEKTF CCCEECCCCCCCEEE | 47.22 | - | |
| 299 | Phosphorylation | PSNGCEKTFSTQYSL CCCCCCEEECCEEEE | 10.67 | 23186163 | |
| 301 | Phosphorylation | NGCEKTFSTQYSLKS CCCCEEECCEEEEHH | 21.60 | 23186163 | |
| 302 | Phosphorylation | GCEKTFSTQYSLKSH CCCEEECCEEEEHHH | 27.60 | 29978859 | |
| 304 | Phosphorylation | EKTFSTQYSLKSHMK CEEECCEEEEHHHHC | 18.96 | 23186163 | |
| 305 | Phosphorylation | KTFSTQYSLKSHMKG EEECCEEEEHHHHCC | 21.36 | 25159151 | |
| 307 | Methylation | FSTQYSLKSHMKGHD ECCEEEEHHHHCCCC | 32.16 | 115973339 | |
| 608 | Phosphorylation | TTAVPVASSPGSSVQ EEEEEECCCCCCCHH | 36.98 | 28348404 | |
| 609 | Phosphorylation | TAVPVASSPGSSVQQ EEEEECCCCCCCHHH | 24.44 | 24719451 | |
| 612 | Phosphorylation | PVASSPGSSVQQIGL EECCCCCCCHHHCCC | 30.62 | 28348404 | |
| 613 | Phosphorylation | VASSPGSSVQQIGLS ECCCCCCCHHHCCCC | 29.84 | 28348404 | |
| 620 | Phosphorylation | SVQQIGLSVPVIIIK CHHHCCCCCCEEEEC | 21.11 | - | |
| 627 | Sumoylation | SVPVIIIKQEEACQC CCCEEEECCHHHHCC | 41.05 | - | |
| 654 | Phosphorylation | SSRRKGCSSPPPPEP HHCCCCCCCCCCCCC | 55.32 | 28348404 | |
| 655 | Phosphorylation | SRRKGCSSPPPPEPS HCCCCCCCCCCCCCC | 45.57 | 28348404 | |
| 677 | Phosphorylation | SLQLPAQTFSSAPVP CCCCCCCEECCCCCC | 27.82 | 28348404 | |
| 679 | Phosphorylation | QLPAQTFSSAPVPGS CCCCCEECCCCCCCC | 29.04 | 28348404 | |
| 680 | Phosphorylation | LPAQTFSSAPVPGSS CCCCEECCCCCCCCC | 32.19 | 28348404 | |
| 690 | Phosphorylation | VPGSSSSTLPSSCEQ CCCCCCCCCCCHHHH | 44.64 | 28348404 | |
| 750 | Phosphorylation | EEMGLTSSFSK---- HHHCCCCCCCC---- | 28.44 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTF1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
