dbPTM

POP1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POP1_CAEEL
UniProt AC	Q10666
Protein Name	Protein pop-1
Gene Name	pop-1
Organism	Caenorhabditis elegans.
Sequence Length	438
Subcellular Localization	Nucleus . Cytoplasm . Predominantly cytoplasmic but phosphorylation by the lit-1/wrm-1 complex causes translocation to the nucleus.
Protein Description	Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. [PubMed: 11742996]
Protein Sequence	MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKEAVMEAELDGAGRNPSIDVLKSAFPKVEPMSPSFPGLMSHFSPGYSAAALPMFMPLFMNPYAAALRSPSLMFPMGAMSPTFPMFPPSPVYGAAIAAAAAKQHFENMAPLNMRAGHPMNQMGMPPYMHPSSMAPQNVDRRAQGGGKAKKDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAVNKKKTKKRRDKSIPSENNDQKKCRARFGVNNTEMWCKFCKRKKKCEYATDRSGGSDITDSQDGRGTSGAYSSSSESPSPKANAGIALTTQQQQAAMMHTMLMQMRLGSTTGASTHVPSPLASSSAGRSPLDANASDSESDVEEEEDEQIDPTVMQQTHDMLMQESMCTI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Phosphorylation	PYAAALRSPSLMFPM HHHHHHCCCCCCCCC	21.49	15066285
109	Phosphorylation	AAALRSPSLMFPMGA HHHHCCCCCCCCCCC	33.44	15066285
118	Phosphorylation	MFPMGAMSPTFPMFP CCCCCCCCCCCCCCC	21.91	15066285
120	Phosphorylation	PMGAMSPTFPMFPPS CCCCCCCCCCCCCCC	32.82	15066285
127	Phosphorylation	TFPMFPPSPVYGAAI CCCCCCCCHHHHHHH	27.51	15066285
185	Acetylation	RRAQGGGKAKKDDHV HHHCCCCCCCCCHHH	61.38	-
187	Acetylation	AQGGGKAKKDDHVKK HCCCCCCCCCHHHCH	61.29	-
188	Acetylation	QGGGKAKKDDHVKKP CCCCCCCCCHHHCHH	73.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
118	S	Phosphorylation	Kinase	LIT-1	Q9U9Y8	GPS
127	S	Phosphorylation	Kinase	LIT-1	Q9U9Y8	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POP1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POP1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGL5_CAEEL	egl-5	physical	20553900
POP1_CAEEL	pop-1	physical	20553900
NHR25_CAEEL	nhr-25	genetic	16890160
BAR1_CAEEL	bar-1	physical	15935762
BAR1_CAEEL	bar-1	physical	11560894
WRM1_CAEEL	wrm-1	physical	11560894
14331_CAEEL	par-5	physical	15066285
WRM1_CAEEL	wrm-1	physical	10380924
EP300_HUMAN	EP300	physical	12651889
CBP1_CAEEL	cbp-1	physical	12651889
UNC37_CAEEL	unc-37	physical	11742996
HDA1_CAEEL	hda-1	physical	11742996

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POP1_CAEEL

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C.elegans."; Lo M.-C., Gay F., Odom R., Shi Y., Lin R.; Cell 117:95-106(2004). Cited for: INTERACTION WITH PAR-5, PHOSPHORYLATION AT SER-118 AND SER-127, ANDMUTAGENESIS OF SER-107; SER-109; SER-118; THR-120 AND SER-127.	15066285 [Abstract]