UniProt ID | POP1_CAEEL | |
---|---|---|
UniProt AC | Q10666 | |
Protein Name | Protein pop-1 | |
Gene Name | pop-1 | |
Organism | Caenorhabditis elegans. | |
Sequence Length | 438 | |
Subcellular Localization | Nucleus . Cytoplasm . Predominantly cytoplasmic but phosphorylation by the lit-1/wrm-1 complex causes translocation to the nucleus. | |
Protein Description | Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. [PubMed: 11742996] | |
Protein Sequence | MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKEAVMEAELDGAGRNPSIDVLKSAFPKVEPMSPSFPGLMSHFSPGYSAAALPMFMPLFMNPYAAALRSPSLMFPMGAMSPTFPMFPPSPVYGAAIAAAAAKQHFENMAPLNMRAGHPMNQMGMPPYMHPSSMAPQNVDRRAQGGGKAKKDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAVNKKKTKKRRDKSIPSENNDQKKCRARFGVNNTEMWCKFCKRKKKCEYATDRSGGSDITDSQDGRGTSGAYSSSSESPSPKANAGIALTTQQQQAAMMHTMLMQMRLGSTTGASTHVPSPLASSSAGRSPLDANASDSESDVEEEEDEQIDPTVMQQTHDMLMQESMCTI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
107 | Phosphorylation | PYAAALRSPSLMFPM HHHHHHCCCCCCCCC | 21.49 | 15066285 | |
109 | Phosphorylation | AAALRSPSLMFPMGA HHHHCCCCCCCCCCC | 33.44 | 15066285 | |
118 | Phosphorylation | MFPMGAMSPTFPMFP CCCCCCCCCCCCCCC | 21.91 | 15066285 | |
120 | Phosphorylation | PMGAMSPTFPMFPPS CCCCCCCCCCCCCCC | 32.82 | 15066285 | |
127 | Phosphorylation | TFPMFPPSPVYGAAI CCCCCCCCHHHHHHH | 27.51 | 15066285 | |
185 | Acetylation | RRAQGGGKAKKDDHV HHHCCCCCCCCCHHH | 61.38 | - | |
187 | Acetylation | AQGGGKAKKDDHVKK HCCCCCCCCCHHHCH | 61.29 | - | |
188 | Acetylation | QGGGKAKKDDHVKKP CCCCCCCCCHHHCHH | 73.56 | - |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of POP1_CAEEL !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of POP1_CAEEL !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
EGL5_CAEEL | egl-5 | physical | 20553900 | |
POP1_CAEEL | pop-1 | physical | 20553900 | |
NHR25_CAEEL | nhr-25 | genetic | 16890160 | |
BAR1_CAEEL | bar-1 | physical | 15935762 | |
BAR1_CAEEL | bar-1 | physical | 11560894 | |
WRM1_CAEEL | wrm-1 | physical | 11560894 | |
14331_CAEEL | par-5 | physical | 15066285 | |
WRM1_CAEEL | wrm-1 | physical | 10380924 | |
EP300_HUMAN | EP300 | physical | 12651889 | |
CBP1_CAEEL | cbp-1 | physical | 12651889 | |
UNC37_CAEEL | unc-37 | physical | 11742996 | |
HDA1_CAEEL | hda-1 | physical | 11742996 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C.elegans."; Lo M.-C., Gay F., Odom R., Shi Y., Lin R.; Cell 117:95-106(2004). Cited for: INTERACTION WITH PAR-5, PHOSPHORYLATION AT SER-118 AND SER-127, ANDMUTAGENESIS OF SER-107; SER-109; SER-118; THR-120 AND SER-127. |