POP1_CAEEL - dbPTM
POP1_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID POP1_CAEEL
UniProt AC Q10666
Protein Name Protein pop-1
Gene Name pop-1
Organism Caenorhabditis elegans.
Sequence Length 438
Subcellular Localization Nucleus . Cytoplasm . Predominantly cytoplasmic but phosphorylation by the lit-1/wrm-1 complex causes translocation to the nucleus.
Protein Description Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. [PubMed: 11742996]
Protein Sequence MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKEAVMEAELDGAGRNPSIDVLKSAFPKVEPMSPSFPGLMSHFSPGYSAAALPMFMPLFMNPYAAALRSPSLMFPMGAMSPTFPMFPPSPVYGAAIAAAAAKQHFENMAPLNMRAGHPMNQMGMPPYMHPSSMAPQNVDRRAQGGGKAKKDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAVNKKKTKKRRDKSIPSENNDQKKCRARFGVNNTEMWCKFCKRKKKCEYATDRSGGSDITDSQDGRGTSGAYSSSSESPSPKANAGIALTTQQQQAAMMHTMLMQMRLGSTTGASTHVPSPLASSSAGRSPLDANASDSESDVEEEEDEQIDPTVMQQTHDMLMQESMCTI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
107PhosphorylationPYAAALRSPSLMFPM
HHHHHHCCCCCCCCC
21.4915066285
109PhosphorylationAAALRSPSLMFPMGA
HHHHCCCCCCCCCCC
33.4415066285
118PhosphorylationMFPMGAMSPTFPMFP
CCCCCCCCCCCCCCC
21.9115066285
120PhosphorylationPMGAMSPTFPMFPPS
CCCCCCCCCCCCCCC
32.8215066285
127PhosphorylationTFPMFPPSPVYGAAI
CCCCCCCCHHHHHHH
27.5115066285
185AcetylationRRAQGGGKAKKDDHV
HHHCCCCCCCCCHHH
61.38-
187AcetylationAQGGGKAKKDDHVKK
HCCCCCCCCCHHHCH
61.29-
188AcetylationQGGGKAKKDDHVKKP
CCCCCCCCCHHHCHH
73.56-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
118SPhosphorylationKinaseLIT-1Q9U9Y8
GPS
127SPhosphorylationKinaseLIT-1Q9U9Y8
GPS

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of POP1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of POP1_CAEEL !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EGL5_CAEELegl-5physical
20553900
POP1_CAEELpop-1physical
20553900
NHR25_CAEELnhr-25genetic
16890160
BAR1_CAEELbar-1physical
15935762
BAR1_CAEELbar-1physical
11560894
WRM1_CAEELwrm-1physical
11560894
14331_CAEELpar-5physical
15066285
WRM1_CAEELwrm-1physical
10380924
EP300_HUMANEP300physical
12651889
CBP1_CAEELcbp-1physical
12651889
UNC37_CAEELunc-37physical
11742996
HDA1_CAEELhda-1physical
11742996

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of POP1_CAEEL

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C.elegans.";
Lo M.-C., Gay F., Odom R., Shi Y., Lin R.;
Cell 117:95-106(2004).
Cited for: INTERACTION WITH PAR-5, PHOSPHORYLATION AT SER-118 AND SER-127, ANDMUTAGENESIS OF SER-107; SER-109; SER-118; THR-120 AND SER-127.

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