UNC37_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNC37_CAEEL
• UniProt AC: O02482
• Protein Name: Transcription factor unc-37
• Gene Name: unc-37
• Organism: Caenorhabditis elegans.
• Sequence Length: 612
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. [PubMed: 9165118 May function with transcription factor mls-1 to promote uterine muscle specification and formation]
• Protein Sequence: MKASYLETLDRIKDEHAEMSKHVNQQRSDIEKVALEKENMNRSYMTYAEVSNTLRSDLRKAEEINKRLQEFIMQSLAPQLSQDNQANCLAALEAFKTASPRENGNGAPALPPGFPPGAAGMLGMMPNMPFGMSPAMSQLFNQFASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQPLAGLQGLEQMNFLAGFNPNLLRQASAAGGFNFLNDPHAQARLAAAIGQIGSRPAYSFKIVDGGVPTPTSFPPDAQKGPGIPTGLKKKMELNHGEVVCAATISRDNSRVYTGGKGCVKIWDVKESDISGATVVNRPPIASLDCLKENYIRSCKLFEDGNTLLIGGEASTVALWDLTTETKTLDLETDSQACYALAMSPDEKLLFACLADGNILIYDIHNKVKVGTLPGHQDGASCLDLSKDGTKLWSGGLDNSVRCWDLAQRKEVAKHDFASQVFSLGCCPNDEWVAVGMENNYVEVLSTTGKEKYQLTQHESCVLSLKFAHSGKFFISTGKDNALNAWRTPYGASLFQLKENSSVLSCDISFDDSLIVTGSGEKKATLYAVEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	Phosphorylation	ANKNGRDSTNSVASS CCCCCCCCCCCCCCC	28.29	21082442
210	Phosphorylation	STNSVASSGASTPSI CCCCCCCCCCCCHHH	28.74	21082442
295	Phosphorylation	IVDGGVPTPTSFPPD EEECCCCCCCCCCCC	36.47	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNC37_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNC37_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNC37_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3C_CAEEL	eif-3.C	physical	18692475
TPM1_CAEEL	lev-11	physical	18692475
TPM3_CAEEL	lev-11	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.