EIF3C_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3C_CAEEL
• UniProt AC: O02328
• Protein Name: Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}
• Gene Name: eif-3.C {ECO:0000255|HAMAP-Rule:MF_03002}
• Organism: Caenorhabditis elegans.
• Sequence Length: 898
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MSRFFHAKEDSDSDTSSSEDEVEDQKVNKSAKFRDDLDFMAGPEEDEKRVVRAQKDKKFDELKGIIKQNRDAKSNKDLNRLLTGFDSLAKAYDKSKTVFQRQNVANPRFYIRSLVEIEDYVNKLWDDKDAKSALSKNNAKALPPLRQKLKKYIKDQQLQDLVTDYRVNPDEDGYETPEDEDDDDFGEVSESKAEKSPGKPSEKAAVSDSDSDSDDDDSSNWSSEPESNSSDDEDSVTKMEQLRRYFLKKEFRVESKDDKKEKKKRVIRVKEAVEEDDDADWTPVNREKSVVHFDPKEEVTHDVMIKKLNEVMSARGKRTTDRNQHVANLRKLLEVSEEKELGLGINVKISFCIISALFELNAKISDHMEYETFMTTLQTVNSLLDLLIGTDRVKLSVTYAEEDENLKDDTQEYRIQGSILIAVQRLDGELAKILQNADCHSNDYIEKLKAEKDMCSLIEKAEKYVELRNDSGIFDKHEVCKVYMMRIEHAYYKYQDQNEEDAGKLMDYLCNKIYTLDDEKRLRQRAMLCHVYYLAVHDKWHRARDLLLMSHMQAIVDHSDVDTQILYNRTICQLGLCAFRHGFIREAHQGLSEIQNTQRAKELLAQAVGTRQHEKTAEQEKIDRSRQVPYHMHINVELMECVYLICSMLLEIPHMASCEFEMRRRMLSRSFHYQLKQSEKASLTGPPENTREHVVAASKAMLNGDWKKCQDYIVNDKMNQKVWNLFHNAETVKGMVVRRIQEESLRTYLLTYSTVYATVSLKKLADLFELSKKDVHSIISKMIIQEELSATLDEPTDCLIMHRVEPSRLQMLALNLSDKLQTLAENNEQILEPRTGRGGYQGPGSWFPGRNERQGDKQKGSGGYQGERRGGQGQDGKRGNWGSQGGQQRRHPQKPRAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	EDSDSDTSSSEDEVE CCCCCCCCCCHHHHH	36.54	21082442
17	Phosphorylation	DSDSDTSSSEDEVED CCCCCCCCCHHHHHH	39.58	21082442
18	Phosphorylation	SDSDTSSSEDEVEDQ CCCCCCCCHHHHHHH	49.16	21082442
174	Phosphorylation	VNPDEDGYETPEDED CCCCCCCCCCCCCCC	29.02	30078680
176	Phosphorylation	PDEDGYETPEDEDDD CCCCCCCCCCCCCCC	24.40	19060867
189	Phosphorylation	DDDFGEVSESKAEKS CCCCCCCCHHHHCCC	31.67	30078680
191	Phosphorylation	DFGEVSESKAEKSPG CCCCCCHHHHCCCCC	29.65	30078680
196	Phosphorylation	SESKAEKSPGKPSEK CHHHHCCCCCCCCCC	30.32	19060867
201	Phosphorylation	EKSPGKPSEKAAVSD CCCCCCCCCCCCCCC	56.04	19530675
282	Phosphorylation	EDDDADWTPVNREKS CCCCCCCCCCCCCCC	20.22	30078680
289	Phosphorylation	TPVNREKSVVHFDPK CCCCCCCCEEECCCC	25.31	30078680
319	Phosphorylation	MSARGKRTTDRNQHV HHHCCCCCCCHHHHH	36.21	18806794
320	Phosphorylation	SARGKRTTDRNQHVA HHCCCCCCCHHHHHH	36.67	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3C_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3C_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3C_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of EIF3C_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.