dbPTM

TPM1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPM1_CAEEL
UniProt AC	Q22866
Protein Name	Tropomyosin isoforms a/b/d/f
Gene Name	lev-11
Organism	Caenorhabditis elegans.
Sequence Length	284
Subcellular Localization	Cytoplasm .
Protein Description	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin..
Protein Sequence	MDAIKKKMQAMKIEKDNALDRADAAEEKVRQITEKLERVEEELRDTQKKMTQTGDDLDKAQEDLSAATSKLEEKEKTVQEAEAEVASLNRRMTLLEEELERAEERLKIATEKLEEATHNVDESERVRKVMENRSLQDEERANTVEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSVQKLQKEVDRLEDELVHEKERYKTISEELDSTFQELSGY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	DKAQEDLSAATSKLE HHHHHHHHHHHHHHH	28.34	30078680
93	Phosphorylation	ASLNRRMTLLEEELE HHHHHHHHHHHHHHH	26.78	28854356
162	Phosphorylation	AEEADRKYDEVARKL HHHHHHHHHHHHHHH	20.45	27067626
206	Phosphorylation	VVGNNLKSLEVSEEK HHHHCCCCCCCCHHH	32.69	19530675
220	Phosphorylation	KALQREDSYEEQIRT HHHHCCCCHHHHHHH	29.68	22923814
221	Phosphorylation	ALQREDSYEEQIRTV HHHCCCCHHHHHHHH	35.49	30078680
276	Phosphorylation	TISEELDSTFQELSG HHHHHHHHHHHHHHC	43.69	30078680
277	Phosphorylation	ISEELDSTFQELSGY HHHHHHHHHHHHHCC	29.07	30078680
282	Phosphorylation	DSTFQELSGY----- HHHHHHHHCC-----	34.98	28854356
284	Phosphorylation	TFQELSGY------- HHHHHHCC-------	16.41	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPM1_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPM1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPM1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TPM1_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPM1_CAEEL

Related Literatures of Post-Translational Modification