CBP1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBP1_CAEEL
• UniProt AC: P34545
• Protein Name: Protein cbp-1
• Gene Name: cbp-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 2017
• Subcellular Localization: Nucleus .
• Protein Description: Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. [PubMed: 19521535]
• Protein Sequence: MDEPPSKKSRADSDYDSGLDALSALESLEAFPTSSKDTDVDNNPSTSAGGSGGPSGSTPHPQGTPQPAPSNNGGFNLQPGQSQPQQPPQNMGGGVNGSVLQELLMNPSQTSNNSPRPQAYPPGQQNAFNRSPMMPNGTPNMMSPPSMGRVPGPSPGGPQPPGPGQPQMRPGQPGMFQGDQQQQMMMGAQGQQFPGMMHRYPYAQGGPPPGAQGMPQGYPGVSRGGPTPGQPMGRGAMMNGAMPRSGPMPTQGRPGIPPNQQAMMQPMMTDRQFMQHGQYGQQRPEFMQQYGRPGGYPMMHQGMMMDSNGQPIRGPNQMMMMSNGHPGMSHGPPNGQPGPQAAAAQHAAQQQAAAQAQAQAAAQQQQQQQREQEAAAAAQRNGAGRATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCSQREKENRDFAAKNQPPPHAACTLPHCSTMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLKRIQDTPLQFSLPDLANLIGVNGNSNGSAEGDGLHQFGSPAMRTGNITNSLFEGFNGNPFQNGPNRGGPRPPGGNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYAIPPSNELAQMLGVEGGRSDVHSEGSSMAVAPSQQNQPWGGAPNSNMHQQIPPNGQVPQVNNSSTFPSSGNSTPNIGASSTVSAMLQPKTEPMDDQNTDSLSSRPPTAIGFGGSSSSTPAPIMNGIVKKEEDPEESSNQAPPSVKDTKDGVAESKPKEQQAKREPTPPPTEDTVFSQEDLIKFLLPVWEKLDKSEDAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVHKKLYAGQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKLAFTPLSLFCYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDRNNMAPKTSFTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKPDNKYLASKLPHNKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQFPEKFPYRTKAVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDVYHELLLGYLDYAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVVEFKDIYKQARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDADGGLGGGDSGKKKSSKNKKNNLKKNAKMNKKKAGSITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEPAVLAKPISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYTCNKCSSPAVWHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIGGGEAGDSAAGGTRYESIQRCIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDACTVPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSHVGGAAPTPSTVSNGTPSNAPTPPVSAGPGPAVKGGGVGQVQMQQHQGSHVGGSGPAGMGQPMNSFGGMPGMGLGPNAQNGPGLPGMNPQMNANQSRYMPNGPGLGQSGAPGQQQQPMYSSGMPMQRPGGLGGMNPQQQPQQQQGHPGLQNPGGRPGGVHGMGQNQPVRNNQDMVMNMQMQNQHQQPPPFDSTLQPQIMKINSRLKAAKTEEERETVFSDLKKTPHLFHAWLRMRENQNLVPNRMQGYSQMSMGSSNLQNLQQQQLQQQQAGAMRGGGGFAPGQNNSQPRAPSGQFASMNPSMQQQYPQQQQGWPQQRQQNPGGMQQNANPYNQFQNRQNMMMMPQQQQPHPSNAGGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	Methylation	TPGQPMGRGAMMNGA CCCCCCCCCCCCCCC	24.36	19521535
388	Phosphorylation	NGAGRATTPGSSMLA CCCCCCCCCCCCCCC	25.35	28854356
544	Phosphorylation	DGLHQFGSPAMRTGN CCCCCCCCCCCCCCC	15.69	28854356
825	Phosphorylation	KEEDPEESSNQAPPS CCCCCCCCCCCCCCC	32.69	21082442
826	Phosphorylation	EEDPEESSNQAPPSV CCCCCCCCCCCCCCC	35.92	21082442
855	Phosphorylation	QQAKREPTPPPTEDT HHHCCCCCCCCCCCC	43.61	28854356
859	Phosphorylation	REPTPPPTEDTVFSQ CCCCCCCCCCCCCCH	52.87	19530675
862	Phosphorylation	TPPPTEDTVFSQEDL CCCCCCCCCCCHHHH	19.74	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBP1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBP1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBP1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POP1_CAEEL	pop-1	physical	12651889
HDA1_CAEEL	hda-1	genetic	11742996
ANM5_CAEEL	prmt-5	physical	19521535
CEP1_CAEEL	cep-1	physical	19521535
CREB1_HUMAN	CREB1	physical	7870179

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.