ANM5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM5_CAEEL
• UniProt AC: P46580
• Protein Name: Protein arginine N-methyltransferase 5 {ECO:0000303|PubMed:19521535}
• Gene Name: prmt-5 {ECO:0000312|WormBase:C34E10.5}
• Organism: Caenorhabditis elegans.
• Sequence Length: 734
• Subcellular Localization: Nucleus .
• Protein Description: Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. [PubMed: 19521535]
• Protein Sequence: MSNRTYADNLFPQQVAEQHEEQMSSGSSPKSNSPSRSISSVEAANSRIHIGWMATTLDVAENLDRHVATFCTRLGEFKYNFVVYPIGGVVRAFWTPNGSAENHPPVIDLPDVQLRNDLWESYVVGKISPWIDCDSSDPAFASLSEEHLLKELSYICYLGLQTMAIELTRISSPRTAAILKKWIWTRNSRFTVWVQLPSAIEKCKDYDAFTIEHVDLWTIWADFRKNCGNFSGVYFQVALTISSELPDELTELKLVDRWKAEPLAAFVIESGLFISGRNGEASIPSAHINLLKHLWTTDALRIVLRATTDTFKYNTSIKSEYSQALRHAVRNVNYRSRPDVGEGSNDSTHYLNVIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVVIYLLGGGRGPIGTKILKSEREYNNTFRQGQESLKVKLYIVEKNPNAIVTLKYMNVRTWKRRVTIIESDMRSLPGIAKDRGFEQPDIIVSELLGSFGDNELSPECLDGVTGFLKPTTISIPQKYTSYVKPIMSTHIHQTIKAQSIPYLSRAIPSHGRGEPELDEDEMWIQKYPQGHVRNNMDQIYVVYLSKYIPLAETTKPVFTFEHPNFMNSSNERSDSIEFVMDRNADLMGFAGYFDLQLYKTVMLSIEPSTHTPGMVSWFPAVIPLRDQLRVGEGDRISLKIDRKVDNTGVWYEWHVEKKKTNGESVSTPIQNPNGESYYMRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	EQHEEQMSSGSSPKS HHHHHHHHCCCCCCC	31.10	30078680
25	Phosphorylation	QHEEQMSSGSSPKSN HHHHHHHCCCCCCCC	37.03	30078680
27	Phosphorylation	EEQMSSGSSPKSNSP HHHHHCCCCCCCCCC	45.47	30078680
28	Phosphorylation	EQMSSGSSPKSNSPS HHHHCCCCCCCCCCC	39.61	30078680
37	Phosphorylation	KSNSPSRSISSVEAA CCCCCCCCCHHHHHH	31.03	19530675
39	Phosphorylation	NSPSRSISSVEAANS CCCCCCCHHHHHHHC	29.58	19060867
40	Phosphorylation	SPSRSISSVEAANSR CCCCCCHHHHHHHCC	23.47	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM5_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM5_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP1_CAEEL	cep-1	physical	19521535
CBP1_CAEEL	cbp-1	physical	19521535

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.