PLS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLS2_HUMAN
• UniProt AC: Q9NRY7
• Protein Name: Phospholipid scramblase 2
• Gene Name: PLSCR2
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Membrane; Single-pass type II membrane protein.; Isoform 1: Nucleus .
• Protein Description: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.; Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain..
• Protein Sequence: MRSWNSLFCLNSSRPPGHIVYPKHQAGHTGKQADHLGSQAFYPGRQHDYLVPPAGTAGIPVQNQPGRPEGVPWMPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESSNMYEIKNSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCCPCCLQEIEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDFEITSLDEQIVVGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYMFFERTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SLFCLNSSRPPGHIV CEEECCCCCCCCEEE	19.11	28464451
47	Ubiquitination	AFYPGRQHDYLVPPA CCCCCCCCCEECCCC	34.30	29901268
116	Ubiquitination	FSFESSNMYEIKNSF HHCCCCCCEEEECCC	4.24	29901268
120	Ubiquitination	SSNMYEIKNSFGQRI CCCCEEEECCCCCEE	10.68	29901268
149	Phosphorylation	CGRSRPFTLRITDNV CCCCCCEEEEEECCC	4.09	24719451
172	S-palmitoylation	RPLRCNCCCCPCCLQ CCCCCCCEECCCCCE	15.43	-
173	S-palmitoylation	PLRCNCCCCPCCLQE CCCCCCEECCCCCEE	20.56	-
174	S-palmitoylation	LRCNCCCCPCCLQEI CCCCCEECCCCCEEE	5.45	-
176	S-palmitoylation	CNCCCCPCCLQEIEI CCCEECCCCCEEEEE	46.88	-
177	S-palmitoylation	NCCCCPCCLQEIEIQ CCEECCCCCEEEEEE	19.69	-
296	Phosphorylation	DYMFFERTR------ HHHHHCCCC------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
149	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLS2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLS2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.