GSTM5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM5_HUMAN
• UniProt AC: P46439
• Protein Name: Glutathione S-transferase Mu 5
• Gene Name: GSTM5
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLNLKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	AIRLLLEYTDSSYVE HHHHHHHHCCHHHHC	18.80	25907765
24	Phosphorylation	IRLLLEYTDSSYVEK HHHHHHHCCHHHHCC	21.74	25907765
26	Phosphorylation	LLLEYTDSSYVEKKY HHHHHCCHHHHCCEE	18.77	28509920
27	Phosphorylation	LLEYTDSSYVEKKYT HHHHCCHHHHCCEEE	35.69	28509920
28	Phosphorylation	LEYTDSSYVEKKYTL HHHCCHHHHCCEEEC	19.31	28509920
41	Phosphorylation	TLGDAPDYDRSQWLN ECCCCCCCCHHHHHH	16.52	25884760
50	Ubiquitination	RSQWLNEKFKLGLDF HHHHHHHHCCCCCCC	46.88	21906983
52	Ubiquitination	QWLNEKFKLGLDFPN HHHHHHCCCCCCCCC	53.35	2190698
61	Ubiquitination	GLDFPNLPYLIDGAH CCCCCCCCEEECCCH	28.64	21906983
62	Phosphorylation	LDFPNLPYLIDGAHK CCCCCCCEEECCCHH	21.32	-
63	Ubiquitination	DFPNLPYLIDGAHKI CCCCCCEEECCCHHH	2.44	21906983
71	Phosphorylation	IDGAHKITQSNAILR ECCCHHHHCHHHHHH	30.65	20068231
73	Phosphorylation	GAHKITQSNAILRYI CCHHHHCHHHHHHHH	21.41	28857561
78	Methylation	TQSNAILRYIARKHN HCHHHHHHHHHHHCC	18.07	-
83	Ubiquitination	ILRYIARKHNLCGET HHHHHHHHCCCCCCC	28.02	-
94	Ubiquitination	CGETEEEKIRVDILE CCCCCCHHHHHHHHH	38.81	-
126	Ubiquitination	DFEKLKPKYLEELPE CHHHHCHHHHHHHHH	61.96	-
126	Acetylation	DFEKLKPKYLEELPE CHHHHCHHHHHHHHH	61.96	-
134	Ubiquitination	YLEELPEKLKLYSEF HHHHHHHHHHHHHHH	49.32	-
136	Ubiquitination	EELPEKLKLYSEFLG HHHHHHHHHHHHHHC	57.35	-
144	Ubiquitination	LYSEFLGKRPWFAGD HHHHHHCCCCCCCCC	58.39	-
199	Ubiquitination	KKISAYMKSSQFLRG HHHHHHHHHHHHHHH	33.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTM5_HUMAN	GSTM5	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
GSTM3_HUMAN	GSTM3	physical	26186194
GSTM4_HUMAN	GSTM4	physical	26186194
ARFG1_HUMAN	ARFGAP1	physical	26186194
GSTM5_HUMAN	GSTM5	physical	21516116
GSTM4_HUMAN	GSTM4	physical	28514442
GSTM3_HUMAN	GSTM3	physical	28514442
ARFG1_HUMAN	ARFGAP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-126, AND MASS SPECTROMETRY.
PubMed: 19608861