GSTM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM4_HUMAN
• UniProt AC: Q03013
• Protein Name: Glutathione S-transferase Mu 4
• Gene Name: GSTM4
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene..
• Protein Sequence: MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDFEKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMTLGYWD ------CCCCCCHHH	22.07	28796482
4	Phosphorylation	----MSMTLGYWDIR ----CCCCCCHHHHH	15.10	28796482
7	Phosphorylation	-MSMTLGYWDIRGLA -CCCCCCHHHHHHHH	11.74	28796482
23	Phosphorylation	AIRLLLEYTDSSYEE HHHHHHHHCCCCHHC	18.80	22817900
24	Phosphorylation	IRLLLEYTDSSYEEK HHHHHHHCCCCHHCC	21.74	22673903
26	Phosphorylation	LLLEYTDSSYEEKKY HHHHHCCCCHHCCCC	27.33	22673903
27	Phosphorylation	LLEYTDSSYEEKKYT HHHHCCCCHHCCCCC	39.10	25307156
28	Phosphorylation	LEYTDSSYEEKKYTM HHHCCCCHHCCCCCC	31.87	22673903
31 (in isoform 2)	Ubiquitination	-	38.86	21906983
31 (in isoform 1)	Ubiquitination	-	38.86	21906983
31	Ubiquitination	TDSSYEEKKYTMGDA CCCCHHCCCCCCCCC	38.86	21906983
31	Ubiquitination	TDSSYEEKKYTMGDA CCCCHHCCCCCCCCC	38.86	-
32	Ubiquitination	DSSYEEKKYTMGDAP CCCHHCCCCCCCCCC	49.59	-
33	Phosphorylation	SSYEEKKYTMGDAPD CCHHCCCCCCCCCCC	17.02	21082442
34	Phosphorylation	SYEEKKYTMGDAPDY CHHCCCCCCCCCCCC	24.45	19060867
41	Phosphorylation	TMGDAPDYDRSQWLN CCCCCCCCCHHHHHH	16.52	28674419
43	Methylation	GDAPDYDRSQWLNEK CCCCCCCHHHHHHHH	25.23	-
50	Ubiquitination	RSQWLNEKFKLGLDF HHHHHHHHCCCCCCC	46.88	21906983
50 (in isoform 2)	Ubiquitination	-	46.88	21906983
50	Ubiquitination	RSQWLNEKFKLGLDF HHHHHHHHCCCCCCC	46.88	21906983
50 (in isoform 1)	Ubiquitination	-	46.88	21906983
52	Ubiquitination	QWLNEKFKLGLDFPN HHHHHHCCCCCCCCC	53.35	21906983
52 (in isoform 1)	Ubiquitination	-	53.35	21906983
52 (in isoform 2)	Ubiquitination	-	53.35	21906983
62	Phosphorylation	LDFPNLPYLIDGAHK CCCCCCCEEECCCHH	21.32	-
71	Phosphorylation	IDGAHKITQSNAILC ECCCHHHHCHHHHHH	30.65	-
73	Phosphorylation	GAHKITQSNAILCYI CCHHHHCHHHHHHHH	21.41	-
79	Phosphorylation	QSNAILCYIARKHNL CHHHHHHHHHHHCCC	8.31	25159151
83	Ubiquitination	ILCYIARKHNLCGET HHHHHHHHCCCCCCC	28.02	-
94	Ubiquitination	CGETEEEKIRVDILE CCCCCHHHHHHHHHH	38.81	-
121	Ubiquitination	VCYSPDFEKLKPEYL HHCCCCHHHHCHHHH	65.93	21906983
132	Ubiquitination	PEYLEELPTMMQHFS HHHHHHHHHHHHHHH	22.87	21906983
138	Ubiquitination	LPTMMQHFSQFLGKR HHHHHHHHHHHHCCC	3.27	21906983
182 (in isoform 1)	Ubiquitination	-	58.18	21906983
182 (in isoform 2)	Ubiquitination	-	58.18	21906983
182	Ubiquitination	LDAFPNLKDFISRFE HHCCCCHHHHHHHHC	58.18	21906983
186	Phosphorylation	PNLKDFISRFEGLEK CCHHHHHHHHCCHHH	30.80	22673903
193 (in isoform 1)	Ubiquitination	-	47.18	21906983
193	Ubiquitination	SRFEGLEKISAYMKS HHHCCHHHHHHHHHH	47.18	21906983
199 (in isoform 1)	Ubiquitination	-	32.38	21906983
199	Ubiquitination	EKISAYMKSSRFLPK HHHHHHHHHCCCCCC	32.38	2190698
199	Acetylation	EKISAYMKSSRFLPK HHHHHHHHHCCCCCC	32.38	21680399
206	Ubiquitination	KSSRFLPKPLYTRVA HHCCCCCCCCEEEEE	50.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APLP1_HUMAN	APLP1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
IGS21_HUMAN	IGSF21	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
P53_HUMAN	TP53	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
GSTM4_HUMAN	GSTM4	physical	10905636

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione