ECT2L_HUMAN - dbPTM
ECT2L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ECT2L_HUMAN
UniProt AC Q008S8
Protein Name Epithelial cell-transforming sequence 2 oncogene-like
Gene Name ECT2L
Organism Homo sapiens (Human).
Sequence Length 904
Subcellular Localization
Protein Description May act as a guanine nucleotide exchange factor (GEF)..
Protein Sequence MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLRFVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMPKCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLERQREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEALEKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAYEMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKIGVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAPTGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFKELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKSRLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKSSMEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
86PhosphorylationTVLPRFISLYIFSFL
HHHHHHHHHHHHHCC		16.6527251275
251PhosphorylationLVLTSLETLPKRSNI
HHHHCHHHCCCCCCC		54.37-
300PhosphorylationISSRIPAYEMVMESV
EECCCCHHHHHHHHH		10.13-
438PhosphorylationILSDWLGSQWGKAPS
HHHHHCCCCCCCCCC		22.1624719451
661PhosphorylationGSQLNTYTNFFNNYP
HHHHHHHCCCCCCCH		24.4228842319
667PhosphorylationYTNFFNNYPVILKTI
HCCCCCCCHHHHHHH		10.4428842319
701PhosphorylationTIVTKMLSLPELLLY
HHHHHHHCHHHHHHC		38.0830631047
710PhosphorylationPELLLYPSRRFEEYL
HHHHHCCCHHHHHHH		23.6430631047
716PhosphorylationPSRRFEEYLNLLYAV
CCHHHHHHHHHHHHH		8.16-
721PhosphorylationEEYLNLLYAVRLHTP
HHHHHHHHHHHCCCC		13.25-
727PhosphorylationLYAVRLHTPAEHVDR
HHHHHCCCCHHHCCC		28.8724719451
738PhosphorylationHVDRGDLTTAIDQIK
HCCCCCHHHHHHHHH		20.9430576142
747PhosphorylationAIDQIKKYKGYIDQM
HHHHHHHHCCHHHHH		12.4930576142
750PhosphorylationQIKKYKGYIDQMKQN
HHHHHCCHHHHHHHC		9.3627067055
801PhosphorylationHCCDEEISFSLRLYE
CCCCCCCCHHHHHHH		16.4424719451
803PhosphorylationCDEEISFSLRLYEHI
CCCCCCHHHHHHHHH		13.0424719451
825PhosphorylationFNDALLVSSRGTSHT
CCCEEEECCCCCCCC		17.8124719451
892PhosphorylationDDKFLWLSVLRNAIK
CCCCHHHHHHHHHHH		13.9224719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ECT2L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ECT2L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ECT2L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ECT2L_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ECT2L_HUMAN

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Related Literatures of Post-Translational Modification

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