dbPTM

MSRE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSRE_HUMAN
UniProt AC	P21757
Protein Name	Macrophage scavenger receptor types I and II
Gene Name	MSR1
Organism	Homo sapiens (Human).
Sequence Length	451
Subcellular Localization	Membrane Single-pass type II membrane protein.
Protein Description	Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). [PubMed: 2251254 Isoform III does not internalize acetylated LDL]
Protein Sequence	MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	FHNQQEDTDSCSESV CCCCCCCCCCCCHHH	29.12	27486199
16	Phosphorylation	NQQEDTDSCSESVKF CCCCCCCCCCHHHEE	22.95	27486199
18	Phosphorylation	QEDTDSCSESVKFDA CCCCCCCCHHHEEEC	36.54	28857561
20	Phosphorylation	DTDSCSESVKFDARS CCCCCCHHHEEECHH	17.83	27486199
27	Phosphorylation	SVKFDARSMTALLPP HHEEECHHCCCCCCC	23.39	26657352
29	Phosphorylation	KFDARSMTALLPPNP EEECHHCCCCCCCCC	18.52	28857561
48	Phosphorylation	SLQEKLKSFKAALIA HHHHHHHHHHHHHHH	42.27	24719451
82	N-linked_Glycosylation	LLKWETKNCSVSSTN HHHHHHCCCCCCCCC	30.62	UniProtKB CARBOHYD
102	N-linked_Glycosylation	QSLTGKGNDSEEEMR HHHCCCCCCCHHHHH	53.79	UniProtKB CARBOHYD
104	Phosphorylation	LTGKGNDSEEEMRFQ HCCCCCCCHHHHHHH	51.40	28857561
143	N-linked_Glycosylation	MDTEHFQNFSMTTDQ CCCHHHHHCCCCCHH	29.98	UniProtKB CARBOHYD
184	N-linked_Glycosylation	SKSLISLNTTLLDLQ HHHHHHHCHHHHHHH	24.99	UniProtKB CARBOHYD
221	N-linked_Glycosylation	KLEERVYNVSAEIMA HHHHHHHHHCHHHHH	20.57	19159218
245	Methylation	QEIKGEVKVLNNITN HHHHHHHEHHHHCCC	36.38	23644510
249	N-linked_Glycosylation	GEVKVLNNITNDLRL HHHEHHHHCCCCCCC	38.00	UniProtKB CARBOHYD
251	Phosphorylation	VKVLNNITNDLRLKD HEHHHHCCCCCCCCC	25.46	-
267	N-linked_Glycosylation	EHSQTLRNITLIQGP CCCHHCCCEEEEECC	34.41	UniProtKB CARBOHYD
424	Phosphorylation	VFCFGRESSIEECKI EEEECCCCCHHHHHH	34.94	29396449
425	Phosphorylation	FCFGRESSIEECKIR EEECCCCCHHHHHHH	29.30	29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSRE_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSRE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSRE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_HUMAN	TRAF6	physical	21460221
NKG7_HUMAN	NKG7	physical	25416956
MALL_HUMAN	MALL	physical	25416956
LERL1_HUMAN	LEPROTL1	physical	25416956
SC22A_HUMAN	SEC22A	physical	25416956
IKIP_HUMAN	IKBIP	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
GT252_HUMAN	COLGALT2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
176807	Prostate cancer (PC)
614266	Barrett esophagus (BE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSRE_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221, AND MASSSPECTROMETRY.	19159218 [Abstract]