RAB3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB3C_HUMAN
• UniProt AC: Q96E17
• Protein Name: Ras-related protein Rab-3C
• Gene Name: RAB3C
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Protein transport. Probably involved in vesicular traffic (By similarity)..
• Protein Sequence: MRHEAPMQMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	ASAQDARYGQKDSSD HHHHHHHCCCCCCCC	26.15	21951684
22	Phosphorylation	ARYGQKDSSDQNFDY HHCCCCCCCCCCHHH	42.73	-
23	Phosphorylation	RYGQKDSSDQNFDYM HCCCCCCCCCCHHHE	54.04	-
29	Phosphorylation	SSDQNFDYMFKLLII CCCCCHHHEEEEEEE	10.58	21951684
44	Phosphorylation	GNSSVGKTSFLFRYA CCCCCCCEEEEEEEC	20.84	23879269
45	Phosphorylation	NSSVGKTSFLFRYAD CCCCCCEEEEEEECC	24.36	23879269
50	Phosphorylation	KTSFLFRYADDSFTS CEEEEEEECCCCHHH	13.67	23879269
54	Phosphorylation	LFRYADDSFTSAFVS EEEECCCCHHHHHHH	30.85	22817900
86	Phosphorylation	IKLQIWDTAGQERYR EEEEEEECCCHHHHH	20.07	28857561
92	Phosphorylation	DTAGQERYRTITTAY ECCCHHHHHHHHHHH	16.03	19060867
94	Phosphorylation	AGQERYRTITTAYYR CCHHHHHHHHHHHHH	17.46	29125462
96	Phosphorylation	QERYRTITTAYYRGA HHHHHHHHHHHHHCC	12.54	-
97	Phosphorylation	ERYRTITTAYYRGAM HHHHHHHHHHHHCCC	14.60	24961811
99	Phosphorylation	YRTITTAYYRGAMGF HHHHHHHHHHCCCEE	7.51	21951684
100	Phosphorylation	RTITTAYYRGAMGFI HHHHHHHHHCCCEEE	10.50	21951684
110	Phosphorylation	AMGFILMYDITNEES CCEEEEEEECCCHHH	10.76	21951684
131	Phosphorylation	WSTQIKTYSWDNAQV CCCEEEEEECCCCEE	11.63	21951684
179	Ubiquitination	TSAKDNINVKQTFER CCCCCCCCHHHHHHH	40.98	32142685
181	Ubiquitination	AKDNINVKQTFERLV CCCCCCHHHHHHHHH	38.85	32142685
196	Phosphorylation	DIICDKMSESLETDP HHHHHHCCHHCCCCH	29.76	24114839
198	Phosphorylation	ICDKMSESLETDPAI HHHHCCHHCCCCHHH	24.97	27732954
201	Phosphorylation	KMSESLETDPAITAA HCCHHCCCCHHHHHH	53.21	29449344
206	Phosphorylation	LETDPAITAAKQNTR CCCCHHHHHHHHCCC	23.75	24114839
209	Ubiquitination	DPAITAAKQNTRLKE CHHHHHHHHCCCCCC	41.43	-
212	Phosphorylation	ITAAKQNTRLKETPP HHHHHHCCCCCCCCC	34.58	24114839
225	Geranylgeranylation	PPPPQPNCAC----- CCCCCCCCCC-----	5.35	-
227	Methylation	PPQPNCAC------- CCCCCCCC-------	6.63	-
227	Geranylgeranylation	PPQPNCAC------- CCCCCCCC-------	6.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
94	T	Phosphorylation	Kinase	LRRK2	Q5S007	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
94	T	Phosphorylation	Phosphorylation of Thr-94 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.	29125462

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB3C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB3C_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.