CPLX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPLX1_HUMAN
• UniProt AC: O14810
• Protein Name: Complexin-1
• Gene Name: CPLX1
• Organism: Homo sapiens (Human).
• Sequence Length: 134
• Subcellular Localization: Cytoplasm, cytosol . Enriched at synaptic-releasing sites in mature neurons.
• Protein Description: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. [PubMed: 21785414 Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse]
• Protein Sequence: MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KQALGGATKDMGKML HHHHCCCCHHHHHHC	30.74	29083192
14	Acetylation	QALGGATKDMGKMLG HHHCCCCHHHHHHCC	45.22	19608861
14	Ubiquitination	QALGGATKDMGKMLG HHHCCCCHHHHHHCC	45.22	33845483
90	Phosphorylation	QAAMEANSEGSLTRP HHHHHHHCCCCCCCC	50.84	27251275
93	Phosphorylation	MEANSEGSLTRPKKA HHHHCCCCCCCCCCC	23.63	28555341
95	Phosphorylation	ANSEGSLTRPKKAIP HHCCCCCCCCCCCCC	46.77	27251275
115	Phosphorylation	EVEEEDESILDTVIK CCHHCCHHHHHHHHH	40.55	19179400

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPLX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPLX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPLX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP25_HUMAN	SNAP25	physical	11832227
VAMP2_HUMAN	VAMP2	physical	11832227
SNP25_HUMAN	SNAP25	physical	12200427
STX1A_HUMAN	STX1A	physical	12200427
FLNA_HUMAN	FLNA	physical	22939629
FUBP2_HUMAN	KHSRP	physical	22939629
PPIA_HUMAN	PPIA	physical	22939629
SC24C_HUMAN	SEC24C	physical	22939629
STAM1_HUMAN	STAM	physical	22939629
GGA2_HUMAN	GGA2	physical	22939629
TACC3_HUMAN	TACC3	physical	22939629
DPY30_HUMAN	DPY30	physical	22939629
LGUL_HUMAN	GLO1	physical	22939629
NDRG3_HUMAN	NDRG3	physical	22939629
PFD5_HUMAN	PFDN5	physical	22939629
S10A9_HUMAN	S100A9	physical	22939629
SGTA_HUMAN	SGTA	physical	22939629
UB2V2_HUMAN	UBE2V2	physical	22939629
UBE2B_HUMAN	UBE2B	physical	22939629
PSMD9_HUMAN	PSMD9	physical	22939629
SNRPA_HUMAN	SNRPA	physical	22939629
PSMD2_HUMAN	PSMD2	physical	22939629
POMP_HUMAN	POMP	physical	22939629
TAGL2_HUMAN	TAGLN2	physical	22939629
RN114_HUMAN	RNF114	physical	22939629
TRIP6_HUMAN	TRIP6	physical	22939629
HBS1L_HUMAN	HBS1L	physical	22939629
JUPI1_HUMAN	HN1	physical	22939629
NEDD8_HUMAN	NEDD8	physical	22939629
NENF_HUMAN	NENF	physical	22939629
NUBP2_HUMAN	NUBP2	physical	22939629
PSF3_HUMAN	GINS3	physical	22939629
ATRAP_HUMAN	AGTRAP	physical	24722188
CKLF5_HUMAN	CMTM5	physical	24722188
CPLX2_HUMAN	CPLX2	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.