CALB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALB1_HUMAN
• UniProt AC: P05937
• Protein Name: Calbindin
• Gene Name: CALB1
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Protein Description: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase..
• Protein Sequence: MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSDGGKLYRTDLALILCAGDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESHLQSS ------CCHHHHHHH	27.31	-
55	Phosphorylation	KKAGLELSPEMKTFV HHCCCCCCHHHHHHH	14.94	23917254
141	Phosphorylation	ANKTVDDTKLAEYTD HCCCCCHHHHHHHHH	24.40	23917254
146	Phosphorylation	DDTKLAEYTDLMLKL CHHHHHHHHHHHHHH	10.43	23917254
147	Phosphorylation	DTKLAEYTDLMLKLF HHHHHHHHHHHHHHH	17.73	23917254
161	Ubiquitination	FDSNNDGKLELTEMA HCCCCCCCEEHHHHH	41.47	-
180	Ubiquitination	VQENFLLKFQGIKMC CCCCHHHHCCCCEEC	37.48	-
187	Glutathionylation	KFQGIKMCGKEFNKA HCCCCEECCCHHHHH	6.30	15049710
189	Ubiquitination	QGIKMCGKEFNKAFE CCCEECCCHHHHHHE	54.96	-
193	Ubiquitination	MCGKEFNKAFELYDQ ECCCHHHHHHEEECC	60.83	-
242	Phosphorylation	KKNIMALSDGGKLYR HHHEEEECCCCEEEE	25.35	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB9_HUMAN	RANBP9	physical	12684061
IMPA1_HUMAN	IMPA1	physical	12176979
CAC1D_HUMAN	CACNA1D	physical	17257825

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.