LYOX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYOX_HUMAN
• UniProt AC: P28300
• Protein Name: Protein-lysine 6-oxidase
• Gene Name: LOX
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Secreted . Secreted, extracellular space.
• Protein Description: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. [PubMed: 26838787 Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity]
• Protein Sequence: MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	N-linked_Glycosylation	AAVPGAANASAQQPR CCCCCCCCCCCCCCC	33.62	UniProtKB CARBOHYD
83	Phosphorylation	VPGAANASAQQPRTP CCCCCCCCCCCCCCC	26.81	21955146
89	O-linked_Glycosylation	ASAQQPRTPILLIRD CCCCCCCCCEEEEEC	22.74	55825463
97	N-linked_Glycosylation	PILLIRDNRTAAART CEEEEECCCCCHHHH	33.10	UniProtKB CARBOHYD
113	O-linked_Glycosylation	TAGSSGVTAGRPRPT CCCCCCCCCCCCCCC	27.24	55825081
120	O-linked_Glycosylation	TAGRPRPTARHWFQA CCCCCCCCHHHHHHC	37.29	55825085
130	O-linked_Glycosylation	HWFQAGYSTSRAREA HHHHCCCCHHHHHHH	20.99	55826175
131	O-linked_Glycosylation	WFQAGYSTSRAREAG HHHCCCCHHHHHHHH	17.47	55826181
132	O-linked_Glycosylation	FQAGYSTSRAREAGA HHCCCCHHHHHHHHC	20.29	55826185
144	N-linked_Glycosylation	AGASRAENQTAPGEV HHCCHHCCCCCCCCC	43.44	UniProtKB CARBOHYD
146	O-linked_Glycosylation	ASRAENQTAPGEVPA CCHHCCCCCCCCCCC	46.53	OGP
155	Phosphorylation	PGEVPALSNLRPPSR CCCCCCHHCCCCCCC	35.60	24719451
172	Phosphorylation	GMVGDDPYNPYKYSD CCCCCCCCCCCCCCC	35.45	30257219
175	Phosphorylation	GDDPYNPYKYSDDNP CCCCCCCCCCCCCCC	20.94	30257219
187	Sulfation	DNPYYNYYDTYERPR CCCCCCCCCCCCCCC	9.73	31152061
355	Other	SPGCYDTYGADIDCQ CCCCHHCCCCCCCCE	13.86	-
355	"2',4',5'-topaquinone"	SPGCYDTYGADIDCQ CCCCHHCCCCCCCCE	13.86	-
384	Phosphorylation	KVSVNPSYLVPESDY EEEECHHHCCCHHHH	16.99	-
413	O-linked_Glycosylation	HAYASGCTISPY--- EEEECCCEEECC---	28.19	55834745

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYOX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYOX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYOX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H11_HUMAN	HIST1H1A	physical	12686141
ELN_HUMAN	ELN	physical	12686141
H2B2E_HUMAN	HIST2H2BE	physical	12686141
SH3K1_HUMAN	SH3KBP1	physical	24167568
CD2AP_HUMAN	CD2AP	physical	24167568
CBL_HUMAN	CBL	physical	24167568
RAF1_HUMAN	RAF1	physical	22438909

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.