PLPP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPP3_HUMAN
• UniProt AC: O14495
• Protein Name: Phospholipid phosphatase 3 {ECO:0000312|HGNC:HGNC:9229}
• Gene Name: PLPP3 {ECO:0000312|HGNC:HGNC:9229}
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions..
• Protein Sequence: MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVDIIDRNNHHNMM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MQNYKYDKAIVP ---CCCCCCCCCCCC		33845483
8	Ubiquitination	MQNYKYDKAIVPESK CCCCCCCCCCCCCCC		33845483
15	Ubiquitination	KAIVPESKNGGSPAL CCCCCCCCCCCCCCC		21906983
19	Phosphorylation	PESKNGGSPALNNNP CCCCCCCCCCCCCCC		30266825
110	Phosphorylation	GEFYRIYYLKKSRST CCHHHEEEECCCCCC		17924679
170	N-linked_Glycosylation	NPDFSQINCSEGYIQ CCCHHHCCCCCCCCC		UniProtKB CARBOHYD
282	Phosphorylation	SDLFKTKTTLSLPAP HHHHCCCCCCCCCCH		29083192
283	Phosphorylation	DLFKTKTTLSLPAPA HHHCCCCCCCCCCHH		29083192
285	Phosphorylation	FKTKTTLSLPAPAIR HCCCCCCCCCCHHHH		29083192
293	Ubiquitination	LPAPAIRKEILSPVD CCCHHHHHHHCCCCC		21906983
297	Phosphorylation	AIRKEILSPVDIIDR HHHHHHCCCCCEECC		19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PLPP3_HUMAN	PPAP2B	physical	14725715
CTND1_HUMAN	CTNND1	physical	20123964
PLPP3_HUMAN	PPAP2B	physical	18215144
PLPP2_HUMAN	PPAP2C	physical	18215144
PLPP1_HUMAN	PPAP2A	physical	18215144

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.