PLPP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPP2_HUMAN
• UniProt AC: O43688
• Protein Name: Phospholipid phosphatase 2 {ECO:0000312|HGNC:HGNC:9230}
• Gene Name: PLPP2 {ECO:0000312|HGNC:HGNC:9230}
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P..
• Protein Sequence: MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	HGLMAGVTITATVIL CCCCCCCEEEEEEEE		25262027
63	Phosphorylation	LMAGVTITATVILVS CCCCCEEEEEEEEEE		25262027
65	Phosphorylation	AGVTITATVILVSAG CCCEEEEEEEEEECC		25262027
70	Phosphorylation	TATVILVSAGEAYLV EEEEEEEECCCEEEE		25262027
75	Phosphorylation	LVSAGEAYLVYTDRL EEECCCEEEEEECCC		25262027
78	Phosphorylation	AGEAYLVYTDRLYSR CCCEEEEEECCCCCC		25262027
79	Phosphorylation	GEAYLVYTDRLYSRS CCEEEEEECCCCCCH		25262027
84	Phosphorylation	VYTDRLYSRSDFNNY EEECCCCCCHHHHHH		24719451
91	Phosphorylation	SRSDFNNYVAAVYKV CCHHHHHHHHHHHHH		18083107
92	Ubiquitination	RSDFNNYVAAVYKVL CHHHHHHHHHHHHHH		21963094
105	Phosphorylation	VLGTFLFGAAVSQSL HHHHHHHHHHHCHHH		24719451
109	Phosphorylation	FLFGAAVSQSLTDLA HHHHHHHCHHHHHHH		18452278
118	Phosphorylation	SLTDLAKYMIGRLRP HHHHHHHHHHHHCCC		-
139	N-linked_Glycosylation	DPDWSRVNCSVYVQL CCCHHHCCEEEEEEH		UniProtKB CARBOHYD
148	Ubiquitination	SVYVQLEKVCRGNPA EEEEEHHHHHCCCCC		21963094
154	Ubiquitination	EKVCRGNPADVTEAR HHHHCCCCCCCCCHH		21963094
169	Ubiquitination	LSFYSGHSSFGMYCM HHHHCCCCHHHHHHH		21963094
201	Ubiquitination	LLRPTVQFFLVAFAL HHHHHHHHHHHHHHH		21963094
208	Ubiquitination	FFLVAFALYVGYTRV HHHHHHHHHHCCCCH		33845483
257	Ubiquitination	RPPQHCLKEEELERK CCCHHCCCHHHHCCC		21963094
263	Ubiquitination	LKEEELERKPSLSLT CCHHHHCCCCCEEEE		21963094
264	Ubiquitination	KEEELERKPSLSLTL CHHHHCCCCCEEEEE		33845483
266	Phosphorylation	EELERKPSLSLTLTL HHHCCCCCEEEEEEE		22167270
268	Phosphorylation	LERKPSLSLTLTLGE HCCCCCEEEEEEECC		22167270
270	Phosphorylation	RKPSLSLTLTLGEAD CCCCEEEEEEECCCC		22167270
272	Phosphorylation	PSLSLTLTLGEADHN CCEEEEEEECCCCCC		26356563
278	Ubiquitination	LTLGEADHNHYGYPH EEECCCCCCCCCCCC		21963094
281	Phosphorylation	GEADHNHYGYPHSSS CCCCCCCCCCCCCCC		27273156
283	Phosphorylation	ADHNHYGYPHSSS-- CCCCCCCCCCCCC--		28152594
285	Ubiquitination	HNHYGYPHSSS---- CCCCCCCCCCC----		33845483
286	Phosphorylation	NHYGYPHSSS----- CCCCCCCCCC-----		28152594
287	Phosphorylation	HYGYPHSSS------ CCCCCCCCC------		28152594
288	Phosphorylation	YGYPHSSS------- CCCCCCCC-------		28152594
289	Phosphorylation	GYPHSSS-------- CCCCCCC--------		24719451
302	Phosphorylation	--------------------- ---------------------		27642862
304	Phosphorylation	----------------------- -----------------------		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
NT2NL_HUMAN	NOTCH2NL	physical	25416956
RABEK_HUMAN	RABEPK	physical	26186194
PLPP2_HUMAN	PPAP2C	physical	18215144
PLPP3_HUMAN	PPAP2B	physical	18215144
PLPP1_HUMAN	PPAP2A	physical	18215144

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.