dbPTM

RHBL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHBL3_HUMAN
UniProt AC	P58872
Protein Name	Rhomboid-related protein 3
Gene Name	RHBDL3
Organism	Homo sapiens (Human).
Sequence Length	404
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors..
Protein Sequence	MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGEHPSPGPAVAA --CCCCCCCCHHHHH	44.38	24719451
127	Ubiquitination	SKALLEEKGLSLSQR HHHHHHHHCCCHHHH	56.63	32142685
141	Phosphorylation	RLIRHVAYETLPREI HHHHHHHHHHCCCCC	14.36	22817900
143	Phosphorylation	IRHVAYETLPREIDR HHHHHHHHCCCCCCC	29.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHBL3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHBL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHBL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTCRA_HUMAN	PTCRA	physical	22795130
E2AK3_HUMAN	EIF2AK3	physical	22795130
BIK_HUMAN	BIK	physical	22795130
TERA_HUMAN	VCP	physical	22795130

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHBL3_HUMAN

Related Literatures of Post-Translational Modification