PTCRA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTCRA_HUMAN
• UniProt AC: Q6ISU1
• Protein Name: Pre T-cell antigen receptor alpha
• Gene Name: PTCRA
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development..
• Protein Sequence: MAGTWLLLLLALGCPALPTGVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQEPLRGTPGGALWLGVLRLLLFKLLLFDLLLTCSCLCDPAGPLPSPATTTRLRALGSHRLHPATETGGREATSSPRPQPRDRRWGDTPPGRKPGSPVWGEGSYLSSYPTCPAQAWCSRSALRAPSSSLGAFFAGDLPPPLQAGAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	N-linked_Glycosylation	PIWFSAGNGSALDAF CEEEECCCCCCCEEH	40.75	20944746
193	Phosphorylation	TRLRALGSHRLHPAT HHHHHHHCCCCCCCC	13.29	23532336
202	Phosphorylation	RLHPATETGGREATS CCCCCCCCCCCCCCC	40.35	22468782
208	Phosphorylation	ETGGREATSSPRPQP CCCCCCCCCCCCCCC	25.61	22468782
209	Phosphorylation	TGGREATSSPRPQPR CCCCCCCCCCCCCCC	45.45	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTCRA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTCRA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTCRA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTC3_HUMAN	NOTCH3	physical	19966856
VIGLN_HUMAN	HDLBP	physical	26186194
HDGR2_HUMAN	HDGFRP2	physical	26186194
TCEA1_HUMAN	TCEA1	physical	26186194
TCEA1_HUMAN	TCEA1	physical	28514442
CGL_HUMAN	CTH	physical	28514442
FEN1_HUMAN	FEN1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"The structural basis for autonomous dimerization of the pre-T-cellantigen receptor.";
Pang S.S., Berry R., Chen Z., Kjer-Nielsen L., Perugini M.A.,King G.F., Wang C., Chew S.H., La Gruta N.L., Williams N.K.,Beddoe T., Tiganis T., Cowieson N.P., Godfrey D.I., Purcell A.W.,Wilce M.C., McCluskey J., Rossjohn J.;
Nature 467:844-848(2010).
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 17-135, SUBUNIT, DISULFIDEBOND, AND GLYCOSYLATION AT ASN-67.
PubMed: 20944746