MRP3_HUMAN - dbPTM
MRP3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRP3_HUMAN
UniProt AC O15438
Protein Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Organism Homo sapiens (Human).
Sequence Length 1527
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity)..
Protein Sequence MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18N-linked_GlycosylationGSKFWDSNLSVHTEN
CHHHHCCCCEEECCC		33.58UniProtKB CARBOHYD
63PhosphorylationLRHHCRGYIILSHLS
HHHHCCHHHHHHHHH		2.5522985185
67PhosphorylationCRGYIILSHLSKLKM
CCHHHHHHHHHHHHH		16.3922985185
102 (in isoform 4)Ubiquitination-16.3521906983
160UbiquitinationRSKILLAKAEGEISD
HHHHHHHHCCCCCCC		47.11-
229PhosphorylationWFTKMAIYGYRHPLE
HHHHHHHHCCCCCCC		9.897459643
231PhosphorylationTKMAIYGYRHPLEEK
HHHHHHCCCCCCCCC		6.707459653
238UbiquitinationYRHPLEEKDLWSLKE
CCCCCCCCCCCCCCH		49.06-
244UbiquitinationEKDLWSLKEEDRSQM
CCCCCCCCHHHHHHH		54.2521906983
244 (in isoform 2)Ubiquitination-54.2521906983
244 (in isoform 1)Ubiquitination-54.2521906983
256 (in isoform 4)Ubiquitination-2.3321906983
265MethylationEAWRKQEKQTARHKA
HHHHHHHHHHHHHHH		50.91-
271UbiquitinationEKQTARHKASAAPGK
HHHHHHHHHHCCCCC		38.18-
278UbiquitinationKASAAPGKNASGEDE
HHHCCCCCCCCCCCC		48.56-
281PhosphorylationAAPGKNASGEDEVLL
CCCCCCCCCCCCEEC		52.7028355574
288 (in isoform 3)Phosphorylation-6.4422210691
292 (in isoform 3)Phosphorylation-50.5222210691
293 (in isoform 3)Phosphorylation-37.7922210691
298PhosphorylationRPRPRKPSFLKALLA
CCCCCCHHHHHHHHH		46.3624719451
309PhosphorylationALLATFGSSFLISAC
HHHHHHCHHHHHHHH		17.4628258704
310PhosphorylationLLATFGSSFLISACF
HHHHHCHHHHHHHHH		25.1728258704
392UbiquitinationIMGVIYRKALVITNS
CCHHHHHEEEECCCC		29.1521906983
392 (in isoform 2)Ubiquitination-29.1521906983
392 (in isoform 1)Ubiquitination-29.1521906983
401 (in isoform 1)Ubiquitination-41.9121906983
401UbiquitinationLVITNSVKRASTVGE
EECCCCCCCCCCHHH		41.9121906983
401 (in isoform 2)Ubiquitination-41.9121906983
479UbiquitinationKMRAFQVKQMKLKDS
HHHHHHEECCCCCHH		33.61-
486PhosphorylationKQMKLKDSRIKLMSE
ECCCCCHHHHHHHHH		34.0320068231
489UbiquitinationKLKDSRIKLMSEILN
CCCHHHHHHHHHHHH		36.71-
492PhosphorylationDSRIKLMSEILNGIK
HHHHHHHHHHHHHHH		31.7420068231
499UbiquitinationSEILNGIKVLKLYAW
HHHHHHHHHEEEEEC		42.80-
509PhosphorylationKLYAWEPSFLKQVEG
EEEECCHHHHHHHCC		31.5324719451
512 (in isoform 1)Ubiquitination-50.7321906983
512UbiquitinationAWEPSFLKQVEGIRQ
ECCHHHHHHHCCCCH		50.7321906983
512 (in isoform 2)Ubiquitination-50.7321906983
570 (in isoform 5)Phosphorylation-7.0725332170
668PhosphorylationGPVGCGKSSLVSALL
CCCCCCHHHHHHHHH		17.7546156751
684UbiquitinationEMEKLEGKVHMKGSV
CHHHHCCCEEECCCE		21.42-
720PhosphorylationKALNPKRYQQTLEAC
CCCCHHHHHHHHHHH		15.8874102599
760PhosphorylationGGQRQRVSLARAVYS
CCHHHHHHHHHHHHC		20.6423532336
767PhosphorylationSLARAVYSDADIFLL
HHHHHHHCCCCEEEE		21.52110736357
803UbiquitinationPEGVLAGKTRVLVTH
CCCCCCCCCEEEEEC		27.79-
864PhosphorylationDQGHLEDSWTALEGA
CCCCCCCCCHHHCCC		19.5622617229
866PhosphorylationGHLEDSWTALEGAED
CCCCCCCHHHCCCCC		25.8928348404
882PhosphorylationEALLIEDTLSNHTDL
HHEEEEEHHCCCCCC		21.2126657352
884PhosphorylationLLIEDTLSNHTDLTD
EEEEEHHCCCCCCCC		28.7626657352
887PhosphorylationEDTLSNHTDLTDNDP
EEHHCCCCCCCCCCC		36.63101661023
890PhosphorylationLSNHTDLTDNDPVTY
HCCCCCCCCCCCCHH		35.2530266825
896PhosphorylationLTDNDPVTYVVQKQF
CCCCCCCHHHHHHHH		18.9169337905
897PhosphorylationTDNDPVTYVVQKQFM
CCCCCCHHHHHHHHH		10.0027259358
908PhosphorylationKQFMRQLSALSSDGE
HHHHHHHHHHCCCCC		20.8730266825
911PhosphorylationMRQLSALSSDGEGQG
HHHHHHHCCCCCCCC		26.5430266825
912PhosphorylationRQLSALSSDGEGQGR
HHHHHHCCCCCCCCC		50.9530266825
931UbiquitinationRHLGPSEKVQVTEAK
CCCCCCCCEEEEECC		42.1621906983
931 (in isoform 2)Ubiquitination-42.1621906983
931 (in isoform 1)Ubiquitination-42.1621906983
938 (in isoform 2)Ubiquitination-40.5521906983
938UbiquitinationKVQVTEAKADGALTQ
CEEEEECCCCCCCCH		40.5521906983
938 (in isoform 1)Ubiquitination-40.5521906983
1006N-linked_GlycosylationAMADSRQNNTSLRLG
HHHHHHCCCHHHHHH		53.27UniProtKB CARBOHYD
1007N-linked_GlycosylationMADSRQNNTSLRLGV
HHHHHCCCHHHHHHH		23.78UniProtKB CARBOHYD
1052UbiquitinationHQALLHNKIRSPQSF
HHHHHCCCCCCCHHH		28.84-
1129PhosphorylationYTLVQRFYAATSRQL
HHHHHHHHHHHHHHH		9.4929496907
1141PhosphorylationRQLKRLESVSRSPIY
HHHHHHHHCCCCCCH		29.9526699800
1143PhosphorylationLKRLESVSRSPIYSH
HHHHHHCCCCCCHHH		36.0026699800
1177 (in isoform 1)Ubiquitination-43.0121906983
1177UbiquitinationFEIISDTKVDANQRS
EEEECCCCCCCCCCC		43.0121906983
1177 (in isoform 2)Ubiquitination-43.0121906983
1248PhosphorylationNWMIRMMSDLESNIV
HHHHHHHHHHHHCEE		29.6920068231
1268PhosphorylationKEYSKTETEAPWVVE
HHHCCCCCCCCCEEC		42.5528348404
1344 (in isoform 1)Ubiquitination-65.2121906983
1344UbiquitinationFRILEAAKGEIRIDG
HHHHHHHCCCEEECC		65.2121906983
1470PhosphorylationLIQATIRTQFDTCTV
HHHHHHHHHCCCCHH		29.7220068231
1474PhosphorylationTIRTQFDTCTVLTIA
HHHHHCCCCHHHHHH		16.0320068231
1476PhosphorylationRTQFDTCTVLTIAHR
HHHCCCCHHHHHHHH		22.2020068231
1479PhosphorylationFDTCTVLTIAHRLNT
CCCCHHHHHHHHHHH		16.2820068231
1498 (in isoform 1)Ubiquitination-49.8221906983
1498UbiquitinationTRVLVLDKGVVAEFD
CEEEEECCCCEEEEC		49.822190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRP3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRP3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRP3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EF2_HUMANEEF2physical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
VDAC3_HUMANVDAC3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00142 Methotrexate (JP16/USP/INN); Mexate (TN)
D00671 Fexofenadine hydrochloride (JP16/USAN); Allegra (TN)
D00895 Delavirdine mesilate (JAN); Delavirdine mesylate (USAN); Rescriptor (TN)
D00896 Efavirenz (JAN/INN); Sustiva (TN)
D01199 Emtricitabine (JAN/USAN/INN); Emtriva (TN)
D02115 Methotrexate sodium; Trexall (TN)
D07782 Delavirdine (INN)
D07958 Fexofenadine (INN); Telfast (TN)
DrugBank
DB02659Cholic Acid
DB00515Cisplatin
DB00257Clotrimazole
DB00286Conjugated Estrogens
DB00091Cyclosporine
DB00997Doxorubicin
DB00773Etoposide
DB00973Ezetimibe
DB00544Fluorouracil
DB00158Folic Acid
DB08884Gadoxetate
DB00143Glutathione
DB01016Glyburide
DB00328Indomethacin
DB00709Lamivudine
DB00650Leucovorin
DB00563Methotrexate
DB01011Metyrapone
DB01115Nifedipine
DB00338Omeprazole
DB01174Phenobarbital
DB01032Probenecid
DB01045Rifampicin
DB01138Sulfinpyrazone
DB00661Verapamil
DB00541Vincristine
Regulatory Network of MRP3_HUMAN

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Related Literatures of Post-Translational Modification

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