GRAK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRAK_HUMAN
• UniProt AC: P49863
• Protein Name: Granzyme K
• Gene Name: GZMK
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Subcellular Localization: Secreted. Cytoplasmic granule.
• Protein Sequence: MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNLVPPHTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	FFLIVGAYMTHVCFN HHHHHHHHHHHHHHC	9.16	25884760
96	Phosphorylation	KNEASKQTLEIKKFI CCHHHHHHEEEEEEC	30.05	-
174	Phosphorylation	TLREVTVTVLSRKLC CHHEHHHHHHHHHHH	13.33	29083192
177	Phosphorylation	EVTVTVLSRKLCNSQ EHHHHHHHHHHHCCC	24.04	29083192
186	Phosphorylation	KLCNSQSYYNGDPFI HHHCCCCCCCCCCCC	8.04	18452278
187	Phosphorylation	LCNSQSYYNGDPFIT HHCCCCCCCCCCCCC	20.23	18452278
214	Phosphorylation	KDSCKGDSGGPLICK CCCCCCCCCCCEEEC	55.08	26657352
252	Phosphorylation	LLTKKYQTWIKSNLV EEEHHHHHHHHHCCC	26.52	-
256	Phosphorylation	KYQTWIKSNLVPPHT HHHHHHHHCCCCCCC	26.68	-
263	Phosphorylation	SNLVPPHTN------ HCCCCCCCC------	48.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRAK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRAK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRAK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	20876349
SET_HUMAN	SET	physical	20876349
NPL4_HUMAN	NPLOC4	physical	20876349
UFD1_HUMAN	UFD1L	physical	20876349
SET_HUMAN	SET	physical	19059912
ACTG_HUMAN	ACTG1	physical	19059912
TBB3_HUMAN	TUBB3	physical	19059912
GOGA2_HUMAN	GOLGA2	physical	19059912
HNRPK_HUMAN	HNRNPK	physical	19059912
SET_HUMAN	SET	physical	17008916
APEX1_HUMAN	APEX1	physical	17008916
HMGB2_HUMAN	HMGB2	physical	17008916
DNLI4_HUMAN	LIG4	physical	21988832
PNKP_HUMAN	PNKP	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.