| UniProt ID | SYT14_HUMAN | |
|---|---|---|
| UniProt AC | Q8NB59 | |
| Protein Name | Synaptotagmin-14 | |
| Gene Name | SYT14 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 555 | |
| Subcellular Localization |
Membrane Single-pass type III membrane protein . Localized in perinuclear and submembranous regions. |
|
| Protein Description | May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.. | |
| Protein Sequence | MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIILMLLLFLYINKKFCFENVGGFPDLGSEYSTRKNSQDKIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQRNYAWETRQKYSPLSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWHALLES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 (in isoform 7) | Phosphorylation | - | 9.19 | 27050516 | |
| 22 | Phosphorylation | LICIRKVSPEAVGFL EEEEEECCHHHHHHH | 21.76 | - | |
| 30 (in isoform 7) | Phosphorylation | - | 20.74 | 27251275 | |
| 76 | Phosphorylation | KNSQDKIYNSYMDKD CCCCCCCHHHHCCCC | 12.09 | 18083107 | |
| 78 | Phosphorylation | SQDKIYNSYMDKDEH CCCCCHHHHCCCCCC | 12.59 | 29083192 | |
| 79 | Phosphorylation | QDKIYNSYMDKDEHG CCCCHHHHCCCCCCC | 13.00 | 29083192 | |
| 87 | Phosphorylation | MDKDEHGSSSESEDE CCCCCCCCCCCHHHH | 32.38 | 30177828 | |
| 88 | Phosphorylation | DKDEHGSSSESEDEA CCCCCCCCCCHHHHH | 42.59 | 30177828 | |
| 89 | Phosphorylation | KDEHGSSSESEDEAL CCCCCCCCCHHHHHH | 47.00 | 30177828 | |
| 91 | Phosphorylation | EHGSSSESEDEALGK CCCCCCCHHHHHHHH | 52.90 | 30177828 | |
| 454 | Phosphorylation | ANRPPNTYVKLTLLN CCCCCCCEEEEEEEH | 11.39 | 18083107 | |
| 458 | Phosphorylation | PNTYVKLTLLNSMGQ CCCEEEEEEEHHCCH | 24.39 | - | |
| 472 | Phosphorylation | QEMSKCKTSIRRGQP HHHHHHHCCHHCCCC | 38.57 | - | |
| 536 | Phosphorylation | EEELNHWTEMKESKG HHHHHHHHHCHHHHC | 20.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYT14_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYT14_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYT14_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SYT14_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| 614229 | Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) | |||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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