5HT2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT2B_HUMAN
• UniProt AC: P41595
• Protein Name: 5-hydroxytryptamine receptor 2B
• Gene Name: HTR2B
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). [PubMed: 8143856]
• Protein Sequence: MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	N-linked_Glycosylation	FVHVISSNWSGLQTE EEEHHHCCCCCCCCC	30.09	UniProtKB CARBOHYD
252	Ubiquitination	QKKAYLVKNKPPQRL HHHHHHHCCCCCCCE	57.57	29967540
296	Phosphorylation	KDKALPNSGDETLMR CCCCCCCCCCCHHHH	45.76	29255136
300	Phosphorylation	LPNSGDETLMRRTST CCCCCCCHHHHHHHC	30.51	29255136
397	S-palmitoylation	AFGRYITCNYRATKS HHCCHHEECHHCCCC	2.82	-
412	Phosphorylation	VKTLRKRSSKIYFRN HHHHHHHCCCCEECC	38.73	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	LNX1	Q8TBB1	PMID:22889411

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGTR1_HUMAN	AGTR1	physical	19023134

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.