RHG06_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG06_HUMAN
• UniProt AC: O43182
• Protein Name: Rho GTPase-activating protein 6
• Gene Name: ARHGAP6
• Organism: Homo sapiens (Human).
• Sequence Length: 974
• Subcellular Localization: Cytoplasm .
• Protein Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology..
• Protein Sequence: MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQRERWQIWELLSTDNPDALPETLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAQSLLHS ------CCHHHHHHH	34.71	30108239
5	Phosphorylation	---MSAQSLLHSVFS ---CCHHHHHHHHHC	32.39	30108239
9	Phosphorylation	SAQSLLHSVFSCSSP CHHHHHHHHHCCCCC	25.48	30108239
12	Phosphorylation	SLLHSVFSCSSPASS HHHHHHHCCCCCCCH	15.78	28857561
14	Phosphorylation	LHSVFSCSSPASSSA HHHHHCCCCCCCHHH	37.85	28857561
15	Phosphorylation	HSVFSCSSPASSSAA HHHHCCCCCCCHHHH	28.90	28857561
18	Phosphorylation	FSCSSPASSSAASAK HCCCCCCCHHHHHHC	28.36	27732954
19	Phosphorylation	SCSSPASSSAASAKG CCCCCCCHHHHHHCC	26.55	27732954
20	Phosphorylation	CSSPASSSAASAKGF CCCCCCHHHHHHCCC	25.92	27732954
23	Phosphorylation	PASSSAASAKGFSKR CCCHHHHHHCCCCHH	30.17	27732954
28	Phosphorylation	AASAKGFSKRKLRQT HHHHCCCCHHHHHHC	39.97	28270605
37	Phosphorylation	RKLRQTRSLDPALIG HHHHHCCCCCHHHHC	40.28	26657352
66	Phosphorylation	GATAGRLYSPSLPAE CCCCCCCCCCCCCHH	19.71	28857561
67	Phosphorylation	ATAGRLYSPSLPAES CCCCCCCCCCCCHHH	16.77	28857561
69	Phosphorylation	AGRLYSPSLPAESLG CCCCCCCCCCHHHHC	40.83	27732954
74	Phosphorylation	SPSLPAESLGPRLAS CCCCCHHHHCHHHHC	40.51	-
84	Methylation	PRLASSSRGPPPRAT HHHHCCCCCCCCCCC	64.68	-
101	Phosphorylation	PPPGPLCSSFSTPST CCCCCCCCCCCCCCC	41.94	27732954
102	Phosphorylation	PPGPLCSSFSTPSTP CCCCCCCCCCCCCCC	23.40	27732954
104	Phosphorylation	GPLCSSFSTPSTPQE CCCCCCCCCCCCCCC	41.16	27732954
105	Phosphorylation	PLCSSFSTPSTPQEK CCCCCCCCCCCCCCC	21.17	27732954
107	Phosphorylation	CSSFSTPSTPQEKSP CCCCCCCCCCCCCCC	53.46	27732954
108	Phosphorylation	SSFSTPSTPQEKSPS CCCCCCCCCCCCCCC	30.14	27732954
113	Phosphorylation	PSTPQEKSPSGSFHF CCCCCCCCCCCCCEE	24.44	27732954
115	Phosphorylation	TPQEKSPSGSFHFDY CCCCCCCCCCCEEEE	54.91	29523821
117	Phosphorylation	QEKSPSGSFHFDYEV CCCCCCCCCEEEEEE	21.64	29523821
128	Methylation	DYEVPLGRGGLKKSM EEEECCCCCCCCHHH	43.63	-
141	Phosphorylation	SMAWDLPSVLAGPAS HHCCCCCHHHCCCCC	36.74	-
181	Phosphorylation	LQQRKFQSPPDSRGH HHHHCCCCCCCCCCC	41.34	27732954
185	Phosphorylation	KFQSPPDSRGHPYVV CCCCCCCCCCCCEEE	46.03	30108239
195	Phosphorylation	HPYVVWKSEGDFTWN CCEEEEECCCCCEEE	30.97	27259358
200	Phosphorylation	WKSEGDFTWNSMSGR EECCCCCEEECCCCC	28.60	27259358
213	Phosphorylation	GRSVRLRSVPIQSLS CCEEEEEECCCCCHH	36.52	18785766
260	Acetylation	KRKKSLRKKLDSLGK HHHHHHHHHHHHHHH	64.08	19809247
264	Phosphorylation	SLRKKLDSLGKEKNK HHHHHHHHHHHHHCC	49.83	29970186
267	Acetylation	KKLDSLGKEKNKDKE HHHHHHHHHHCCCCC	71.46	19809255
269	Acetylation	LDSLGKEKNKDKEFI HHHHHHHHCCCCCCH	73.17	19809263
328	Phosphorylation	KRQNKELSSSNSSLS HHHCCCCCCCCCCCC	32.58	27732954
329	Phosphorylation	RQNKELSSSNSSLSS HHCCCCCCCCCCCCC	46.28	26657352
330	Phosphorylation	QNKELSSSNSSLSST HCCCCCCCCCCCCCC	37.04	26657352
332	Phosphorylation	KELSSSNSSLSSTSE CCCCCCCCCCCCCCC	34.30	27732954
333	Phosphorylation	ELSSSNSSLSSTSET CCCCCCCCCCCCCCC	36.20	26657352
335	Phosphorylation	SSSNSSLSSTSETPN CCCCCCCCCCCCCCC	33.25	27732954
336	Phosphorylation	SSNSSLSSTSETPNE CCCCCCCCCCCCCCC	41.04	27732954
337	Phosphorylation	SNSSLSSTSETPNES CCCCCCCCCCCCCCC	27.49	26657352
338	Phosphorylation	NSSLSSTSETPNEST CCCCCCCCCCCCCCC	41.23	27732954
340	Phosphorylation	SLSSTSETPNESTSP CCCCCCCCCCCCCCC	31.05	27732954
344	Phosphorylation	TSETPNESTSPNTPE CCCCCCCCCCCCCCC	40.60	28060719
345	Phosphorylation	SETPNESTSPNTPEP CCCCCCCCCCCCCCC	41.86	26434776
346	Phosphorylation	ETPNESTSPNTPEPA CCCCCCCCCCCCCCC	25.98	26434776
349	Phosphorylation	NESTSPNTPEPAPRA CCCCCCCCCCCCCHH	32.20	29255136
363	Phosphorylation	ARRRGAMSVDSITDL HHHCCCCCCCCCCCC	23.41	30108239
366	Phosphorylation	RGAMSVDSITDLDDN CCCCCCCCCCCCCCC	25.82	29970186
368	Phosphorylation	AMSVDSITDLDDNQS CCCCCCCCCCCCCHH	34.17	25262027
384	Phosphorylation	LLEALQLSLPAEAQS HHHHHHHHCCHHHHH	21.24	23285258
391	Phosphorylation	SLPAEAQSKKEKARD HCCHHHHHHHHHHHH	53.39	27535140
402	Phosphorylation	KARDKKLSLNPIYRQ HHHHHCCCCCHHHHH	34.67	28060719
407	Phosphorylation	KLSLNPIYRQVPRLV CCCCCHHHHHHHHHH	9.03	22817900
545	Phosphorylation	SKDGQEVTGNKMTSL CCCCCEECCCCCCEE	33.99	29396449
551	Phosphorylation	VTGNKMTSLNLATIF ECCCCCCEEEHHHHH	16.26	18088087
569	Phosphorylation	LLHKQKSSDKEFSVQ HHHCCCCCCCCCCHH	60.79	20058876
574	Phosphorylation	KSSDKEFSVQSSARA CCCCCCCCHHHHCCH	21.97	18088087
584	Phosphorylation	SSARAEESTAIIAVV HHCCHHHHHHHHHHH	18.04	29514088
585	Phosphorylation	SARAEESTAIIAVVQ HCCHHHHHHHHHHHH	25.75	29514088
633	Phosphorylation	YLLRRKASQSSSPDM HHHHHHHCCCCCCCH	33.36	28060719
635	Phosphorylation	LRRKASQSSSPDMLQ HHHHHCCCCCCCHHH	30.23	23186163
636	Phosphorylation	RRKASQSSSPDMLQS HHHHCCCCCCCHHHC	37.95	28060719
637	Phosphorylation	RKASQSSSPDMLQSE HHHCCCCCCCHHHCE	30.11	28060719
643	Phosphorylation	SSPDMLQSEVSFSVG CCCCHHHCEEEEECC	35.68	23186163
646	Phosphorylation	DMLQSEVSFSVGGRH CHHHCEEEEECCCCC	14.04	23532336
648	Phosphorylation	LQSEVSFSVGGRHSS HHCEEEEECCCCCCC	16.61	23532336
654	Phosphorylation	FSVGGRHSSTDSNKA EECCCCCCCCCCCCC	33.31	28270605
655	Phosphorylation	SVGGRHSSTDSNKAS ECCCCCCCCCCCCCC	30.06	28270605
656	Phosphorylation	VGGRHSSTDSNKASS CCCCCCCCCCCCCCC	46.60	28270605
658	Phosphorylation	GRHSSTDSNKASSGD CCCCCCCCCCCCCCC	40.08	28270605
662	Phosphorylation	STDSNKASSGDISPY CCCCCCCCCCCCCCC	36.14	30108239
663	Phosphorylation	TDSNKASSGDISPYD CCCCCCCCCCCCCCC	45.40	23898821
667	Phosphorylation	KASSGDISPYDNNSP CCCCCCCCCCCCCCC	23.34	23898821
669	Phosphorylation	SSGDISPYDNNSPVL CCCCCCCCCCCCCCC	25.22	30108239
673	Phosphorylation	ISPYDNNSPVLSERS CCCCCCCCCCCCHHH	23.73	22499768
677	Phosphorylation	DNNSPVLSERSLLAM CCCCCCCCHHHHHHH	31.06	27732954
680	Phosphorylation	SPVLSERSLLAMQED CCCCCHHHHHHHHCC	24.55	27732954
710	Phosphorylation	FMLVGHLSSSKSRES EEEEEEECCCCCCCC	27.22	23186163
711	Phosphorylation	MLVGHLSSSKSRESS EEEEEECCCCCCCCC	48.41	23917254
712	Phosphorylation	LVGHLSSSKSRESSP EEEEECCCCCCCCCC	31.13	23186163
737	Phosphorylation	EPFDIWGTWHSTLKS CCCCCCHHHHHCCCC	12.66	28060719
740	Phosphorylation	DIWGTWHSTLKSGSK CCCHHHHHCCCCCCC	27.31	28060719
741	Phosphorylation	IWGTWHSTLKSGSKD CCHHHHHCCCCCCCC	25.89	28060719
744	Phosphorylation	TWHSTLKSGSKDPGM HHHHCCCCCCCCCCC	51.95	28060719
746	Phosphorylation	HSTLKSGSKDPGMTG HHCCCCCCCCCCCCC	40.76	26434776
752	Phosphorylation	GSKDPGMTGSSGDIF CCCCCCCCCCCCCCC	39.57	25219547
754	Phosphorylation	KDPGMTGSSGDIFES CCCCCCCCCCCCCCC	23.21	28348404
755	Phosphorylation	DPGMTGSSGDIFESS CCCCCCCCCCCCCCC	41.66	25219547
770	Phosphorylation	SLRAGPCSLSQGNLS CCCCCCCCCCCCCCC	33.90	27732954
772	Phosphorylation	RAGPCSLSQGNLSPN CCCCCCCCCCCCCCC	21.54	20058876
777	Phosphorylation	SLSQGNLSPNWPRWQ CCCCCCCCCCCCCCC	21.86	27499020
786	Phosphorylation	NWPRWQGSPAELDSD CCCCCCCCCCCCCCC	13.06	28060719
820	Phosphorylation	PAVSRACSTPHVQVA HHHHHHHCCCCEEEC	43.94	28348404
821	Phosphorylation	AVSRACSTPHVQVAG HHHHHHCCCCEEECC	19.80	27732954
834	Phosphorylation	AGKAERPTARSEQYL CCCCCCCCCCCHHEE	40.71	28270605
837	Phosphorylation	AERPTARSEQYLTLS CCCCCCCCHHEEEEC	26.96	27732954
840	Phosphorylation	PTARSEQYLTLSGAH CCCCCHHEEEECCCC	9.52	27732954
842	Phosphorylation	ARSEQYLTLSGAHDL CCCHHEEEECCCCCC	17.59	27732954
844	Phosphorylation	SEQYLTLSGAHDLSE CHHEEEECCCCCCCH	28.79	27732954
850	Phosphorylation	LSGAHDLSESELDVA ECCCCCCCHHHCCCC	45.17	27732954
852	Phosphorylation	GAHDLSESELDVAGL CCCCCCHHHCCCCHH	39.83	27732954
927	Phosphorylation	QVTQKKLSSANSLPA HHHHHHHHHCCCCCC	35.96	26657352
928	Phosphorylation	VTQKKLSSANSLPAG HHHHHHHHCCCCCCC	41.74	25850435
931	Phosphorylation	KKLSSANSLPAGEQD HHHHHCCCCCCCCCC	35.13	22499768
939	Phosphorylation	LPAGEQDSPRLGDAG CCCCCCCCCCCCCCC	16.18	10699171
962	Phosphorylation	WQIWELLSTDNPDAL HHHHHHHHCCCCCCC	46.47	27251275
963	Phosphorylation	QIWELLSTDNPDALP HHHHHHHCCCCCCCC	39.50	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG06_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG06_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG06_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RHG06_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264; SER-663; SER-673;SER-754; SER-777; SER-928 AND SER-939, AND MASS SPECTROMETRY.
PubMed: 18088087