SC6A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC6A5_HUMAN
• UniProt AC: Q9Y345
• Protein Name: Sodium- and chloride-dependent glycine transporter 2
• Gene Name: SLC6A5
• Organism: Homo sapiens (Human).
• Sequence Length: 797
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses..
• Protein Sequence: MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	PRVPRSASTGAQTFQ CCCCCCCCCCCCCHH	28.72	-
57	Phosphorylation	RVPRSASTGAQTFQS CCCCCCCCCCCCHHH	35.93	-
61	Phosphorylation	SASTGAQTFQSADAR CCCCCCCCHHHHCHH	24.10	-
83	Phosphorylation	GVGSCKLSSPRAQAA CCCCCCCCCHHHHHH	24.64	24719451
84	Phosphorylation	VGSCKLSSPRAQAAS CCCCCCCCHHHHHHH	28.92	17081983
91	Phosphorylation	SPRAQAASAALRDLR CHHHHHHHHHHHHHH	19.65	-
343	N-linked_Glycosylation	HPKIQIKNSTFCMTA CCCEEECCCEEEEEC	48.16	11036075
343	N-linked_Glycosylation	HPKIQIKNSTFCMTA CCCEEECCCEEEEEC	48.16	11036075
353	N-linked_Glycosylation	FCMTAYPNVTMVNFT EEEECCCCEEEEEEC	29.25	11036075
353	N-linked_Glycosylation	FCMTAYPNVTMVNFT EEEECCCCEEEEEEC	29.25	11036075
358	N-linked_Glycosylation	YPNVTMVNFTSQANK CCCEEEEEECCCCCC	24.53	11036075
358	N-linked_Glycosylation	YPNVTMVNFTSQANK CCCEEEEEECCCCCC	24.53	11036075
364	N-linked_Glycosylation	VNFTSQANKTFVSGS EEECCCCCCCEECCC	35.94	UniProtKB CARBOHYD
364	N-linked_Glycosylation	VNFTSQANKTFVSGS EEECCCCCCCEECCC	35.94	11036075

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC6A5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC6A5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC6A5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX1A_HUMAN	STX1A	physical	10722844
GBB2_HUMAN	GNB2	physical	28514442
TBC24_HUMAN	TBC1D24	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
GBG5_HUMAN	GNG5	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
RETR3_HUMAN	FAM134C	physical	28514442
NAT14_HUMAN	NAT14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00769: Hyperekplexia
• OMIM Disease
• 614618: Hyperekplexia 3 (HKPX3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine