INSC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INSC_HUMAN
• UniProt AC: Q1MX18
• Protein Name: Protein inscuteable homolog
• Gene Name: INSC
• Organism: Homo sapiens (Human).
• Sequence Length: 579
• Subcellular Localization: Cytoplasm . Cytoplasm, cell cortex . Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles.
• Protein Description: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. [PubMed: 16458856 Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity]
• Protein Sequence: MRRPPGNGEAASEGPGGWGLWGVQESRRLCCAGHDRCKQALLQIGINMMALPGGRHLDSVTLPGQRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	LHLMQVDSVQRWMED EEEEEHHHHHHHHHH	22.69	-
210	Acetylation	VENEHVLKSMKACVS HCCHHHHHHHHHHHH	47.63	18530545
217	Phosphorylation	KSMKACVSETLSMLG HHHHHHHHHHHHHHH	25.42	-
219 (in isoform 5)	Phosphorylation	-	19.34	29743597
222 (in isoform 5)	Phosphorylation	-	5.69	29743597
225 (in isoform 5)	Phosphorylation	-	25.44	29743597
227 (in isoform 5)	Phosphorylation	-	5.25	29743597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INSC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INSC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INSC_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of INSC_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.