| UniProt ID | LGR6_HUMAN | |
|---|---|---|
| UniProt AC | Q9HBX8 | |
| Protein Name | Leucine-rich repeat-containing G-protein coupled receptor 6 | |
| Gene Name | LGR6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 967 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.. | |
| Protein Sequence | MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 (in isoform 1) | Phosphorylation | - | 2.50 | - | |
| 77 | N-linked_Glycosylation | YLDLSMNNLTELQPG HHCCCCCCCCHHCCC | 39.43 | UniProtKB CARBOHYD | |
| 115 | Phosphorylation | QAFSGLYSLKILMLQ CHHHHHHHHHEEECC | 28.38 | 24719451 | |
| 162 | Phosphorylation | ERSFEGLSSLRHLWL CCCCCCHHHCCEEEC | 37.88 | 30301811 | |
| 163 | Phosphorylation | RSFEGLSSLRHLWLD CCCCCHHHCCEEECC | 34.17 | 25954137 | |
| 208 | N-linked_Glycosylation | IPDYAFQNLTSLVVL CCHHHHHCCHHEEEE | 38.54 | UniProtKB CARBOHYD | |
| 255 | Phosphorylation | EFPVAIRTLGRLQEL HHHHHHHHHHHHHHH | 27.70 | - | |
| 318 | Phosphorylation | SLNGAMDIQEFPDLK EECCCCCHHHCCCCC | 2.44 | 17525332 | |
| 405 | Phosphorylation | SSLQALDLSWNAIRS HHHHHHHCCHHHHHH | 7.12 | 32142685 | |
| 412 | Phosphorylation | LSWNAIRSIHPEAFS CCHHHHHHHCHHHHH | 21.09 | 26126808 | |
| 419 | Phosphorylation | SIHPEAFSTLHSLVK HHCHHHHHHHHHHHC | 36.79 | 26126808 | |
| 420 | Phosphorylation | IHPEAFSTLHSLVKL HCHHHHHHHHHHHCC | 23.26 | 26126808 | |
| 423 | Phosphorylation | EAFSTLHSLVKLDLT HHHHHHHHHHCCCCC | 37.66 | 26126808 | |
| 457 | Phosphorylation | LKGNLALSQAFSKDS ECCCCHHHHCCCCCC | 17.54 | 17525332 | |
| 477 | Phosphorylation | ILEVPYAYQCCPYGM EEECCCHHHCCCCCH | 9.02 | 30576142 | |
| 482 | Phosphorylation | YAYQCCPYGMCASFF CHHHCCCCCHHHHHH | 11.99 | 30576142 | |
| 685 | Phosphorylation | GKSPSLGSVRAGVLG CCCCCHHHHHHHHHH | 17.45 | 24719451 | |
| 810 | Phosphorylation | VTPEAVKSVLLVVLP CCHHHHHHHHHHCCC | 16.05 | - | |
| 827 | Phosphorylation | ACLNPLLYLLFNPHF HHHHHHHHHHHCHHH | 14.72 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LGR6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LGR6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LGR6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LGR6_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457, AND MASSSPECTROMETRY. | |
