CATO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATO_HUMAN
• UniProt AC: P43234
• Protein Name: Cathepsin O
• Gene Name: CTSO
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Subcellular Localization: Lysosome.
• Protein Description: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover..
• Protein Sequence: MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	ADSRAPFTPTWPRSR CCCCCCCCCCCCCHH	20.81	29396449
32	Phosphorylation	SRAPFTPTWPRSRER CCCCCCCCCCCHHHH	45.07	29396449
62	N-linked_Glycosylation	NSLFPSENSTAFYGI HHHCCCCCCCCEEEC	49.34	UniProtKB CARBOHYD
105	N-linked_Glycosylation	EVHMSIPNVSLPLRF EEEECCCCCCCCEEE	34.05	UniProtKB CARBOHYD
107	Phosphorylation	HMSIPNVSLPLRFDW EECCCCCCCCEEEEC	30.80	24719451
117	Ubiquitination	LRFDWRDKQVVTQVR EEEECCCHHHHHHCC	36.10	-
145	Phosphorylation	VGAVESAYAIKGKPL HHHHHHHHHCCCCCH	20.38	18083107
208	Phosphorylation	NGLCHYFSGSHSGFS CCCEEECCCCCCCCE	32.02	30576142
212	Phosphorylation	HYFSGSHSGFSIKGY EECCCCCCCCEEECE	43.14	30576142
215	Phosphorylation	SGSHSGFSIKGYSAY CCCCCCCEEECEECC	27.24	30576142
294	Phosphorylation	VRNSWGSSWGVDGYA EECCCCCCCCCCCCE	24.74	24719451
315	Phosphorylation	NVCGIADSVSSIFV- CCCCCCCCCEECCC-	18.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CATO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LYPA1_HUMAN	LYPLA1	physical	26186194
GRN_HUMAN	GRN	physical	26186194
AMZ2_HUMAN	AMZ2	physical	26186194
LYPA1_HUMAN	LYPLA1	physical	28514442
GRN_HUMAN	GRN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.