GIPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIPR_HUMAN
• UniProt AC: P48546
• Protein Name: Gastric inhibitory polypeptide receptor
• Gene Name: GIPR
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase..
• Protein Sequence: MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	PPSGLACNGSFDMYV CCCCCCCCCEEEEEE	43.46	22412906
77	N-linked_Glycosylation	CWDYAAPNATARASC EECHHCCCCCCCCCC	45.24	22412906
160	Phosphorylation	LLALLILSLFRRLHC HHHHHHHHHHHHHCC	20.61	24719451
301	Phosphorylation	AIWWIIRTPILMTIL HHHHHHHHHHHHHHH	12.31	22210691
306	Phosphorylation	IRTPILMTILINFLI HHHHHHHHHHHHHHH	14.80	22210691
342	Phosphorylation	YRLRLARSTLTLVPL HHHHHHHHHHHHHHH	23.35	24719451
345	Phosphorylation	RLARSTLTLVPLLGV HHHHHHHHHHHHCCC	26.29	24719451
381	Phosphorylation	LGFEIFLSSFQGFLV HCHHHHHHHHHHHHH	20.54	-
382	Phosphorylation	GFEIFLSSFQGFLVS CHHHHHHHHHHHHHH	24.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	LNX1	Q8TBB1	PMID:22889411

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIPR_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GIPR_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.