SPKAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPKAP_HUMAN
• UniProt AC: Q2M3C7
• Protein Name: A-kinase anchor protein SPHKAP
• Gene Name: SPHKAP
• Organism: Homo sapiens (Human).
• Sequence Length: 1700
• Subcellular Localization: Cytoplasm . Colocalizes with SPHK1 in the cytoplasm.
• Protein Description: Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1..
• Protein Sequence: MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDGNSLLSVPSN ---CCCCCCCCCCCC	35.90	24043423
8	Phosphorylation	MDGNSLLSVPSNLES CCCCCCCCCCCCCCC	36.96	24043423
11	Phosphorylation	NSLLSVPSNLESSRM CCCCCCCCCCCCCCC	52.47	24043423
15	Phosphorylation	SVPSNLESSRMYDVL CCCCCCCCCCCCEEC	26.81	24043423
16	Phosphorylation	VPSNLESSRMYDVLE CCCCCCCCCCCEECC	16.22	24043423
19	Phosphorylation	NLESSRMYDVLEPQQ CCCCCCCCEECCCCC	11.20	24043423
32	Phosphorylation	QQGRGCGSSGSGPGN CCCCCCCCCCCCCCH	35.29	25072903
33	Phosphorylation	QGRGCGSSGSGPGNS CCCCCCCCCCCCCHH	23.43	25072903
35	Phosphorylation	RGCGSSGSGPGNSIT CCCCCCCCCCCHHHH	43.70	25072903
40	Phosphorylation	SGSGPGNSITACKKV CCCCCCHHHHHHHHH	27.51	25072903
42	Phosphorylation	SGPGNSITACKKVLR CCCCHHHHHHHHHHH	26.31	25072903
50	Phosphorylation	ACKKVLRSNSLLEST HHHHHHHHCCHHHCC	26.98	28348404
52	Phosphorylation	KKVLRSNSLLESTDY HHHHHHCCHHHCCHH	35.26	22912867
167	Phosphorylation	ARGNRPNSTNCIIFE CCCCCCCCCCEEEEE	24.55	26471730
168	Phosphorylation	RGNRPNSTNCIIFEI CCCCCCCCCEEEEEE	40.52	26471730
253	Phosphorylation	SKQLKGATQVEWNCN CCCCCCCEEEEECCC	41.64	30622161
266	Phosphorylation	CNKEKWLYALEDKYI CCHHHHHHHHHHHHH	14.18	-
272	Phosphorylation	LYALEDKYINKYPTP HHHHHHHHHHCCCCC	23.27	-
276	Phosphorylation	EDKYINKYPTPLIKT HHHHHHCCCCCCCCC	14.09	-
278	Phosphorylation	KYINKYPTPLIKTER HHHHCCCCCCCCCCC	27.86	24719451
286	Phosphorylation	PLIKTERSPENLTKN CCCCCCCCCCCCCCC	30.27	32142685
291	Phosphorylation	ERSPENLTKNTALQS CCCCCCCCCCHHHHH	33.55	22817900
304	Ubiquitination	QSLDPSAKPSQWKRE HHCCCCCCHHHCHHH	49.92	-
443	Phosphorylation	KDTVVSRSWNELPKI CCCEEECCHHCCCCE	27.09	27251275
621	Ubiquitination	AIAKGLLKEAALVLT HHHHHHHHHHHHHHC	50.80	29967540
632	Phosphorylation	LVLTRPNTYSSIGDF HHHCCCCCCHHHHHH	27.71	30576142
633	Phosphorylation	VLTRPNTYSSIGDFL HHCCCCCCHHHHHHH	13.68	30576142
642	Phosphorylation	SIGDFLDSMNRRIME HHHHHHHHHHHHHHH	21.80	30576142
793	Phosphorylation	NLVDGMYSKQDKGGV CHHHCCCCCCCCCCC	18.23	24719451
809	Phosphorylation	PGLFKNPTLQSQLSR CCCCCCHHHHHHHHH	46.99	27251275
812	Phosphorylation	FKNPTLQSQLSRSHR CCCHHHHHHHHHHCC	35.88	27251275
815	Phosphorylation	PTLQSQLSRSHRVPD HHHHHHHHHHCCCCC	24.89	27251275
856	Phosphorylation	SENECRASSEGQRSP CCCCCCCCCCCCCCC	15.01	26699800
857	Phosphorylation	ENECRASSEGQRSPT CCCCCCCCCCCCCCC	44.77	26699800
862	Phosphorylation	ASSEGQRSPTVSQSR CCCCCCCCCCCCCCC	19.62	26699800
864	Phosphorylation	SEGQRSPTVSQSRSG CCCCCCCCCCCCCCC	33.75	22210691
868	Phosphorylation	RSPTVSQSRSGSQEA CCCCCCCCCCCCHHH	22.40	22210691
870	Phosphorylation	PTVSQSRSGSQEAEE CCCCCCCCCCHHHHH	48.30	28348404
872	Phosphorylation	VSQSRSGSQEAEESI CCCCCCCCHHHHHHC	26.54	24719451
878	Phosphorylation	GSQEAEESIHPNTQE CCHHHHHHCCCCHHH	20.08	28348404
971	Phosphorylation	RGSEFLMTPNVPCRS CCCCEECCCCCCHHH	17.54	-
1025	Phosphorylation	MNRVVDESMNLEDVP HHHHHCCCCCCCCCC	14.43	-
1071	Phosphorylation	YPRNRLLSGDRWSRL CCCCCCCCCCHHHHH	43.15	24719451
1082	Phosphorylation	WSRLKASSCESIPEE HHHHCHHCCCCCCCC	27.11	24719451
1085	Phosphorylation	LKASSCESIPEEDSE HCHHCCCCCCCCHHH	48.01	24719451
1104	Phosphorylation	VNSLGLMSTLSQPVS HHHHCHHHHHCCCCH	31.10	27251275
1105	Phosphorylation	NSLGLMSTLSQPVSR HHHCHHHHHCCCCHH	19.23	27251275
1107	Phosphorylation	LGLMSTLSQPVSRAS HCHHHHHCCCCHHHH	32.31	24719451
1120	Phosphorylation	ASSVSKQSSCESITD HHCCCCHHCCHHHHH	40.47	-
1121	Phosphorylation	SSVSKQSSCESITDE HCCCCHHCCHHHHHH	21.29	-
1124	Phosphorylation	SKQSSCESITDEFSR CCHHCCHHHHHHHHH	34.81	-
1157	Phosphorylation	YYAGKNASSILNSAM HHCCCCHHHHHHHHH	27.57	23403867
1158	Phosphorylation	YAGKNASSILNSAMQ HCCCCHHHHHHHHHH	28.78	23403867
1162	Phosphorylation	NASSILNSAMQQACR CHHHHHHHHHHHHHH	22.98	23403867
1185	Phosphorylation	PSCPSKQSSTESITE CCCCCCCCCCCCHHH	42.85	25072903
1186	Phosphorylation	SCPSKQSSTESITEE CCCCCCCCCCCHHHH	33.43	25072903
1187	Phosphorylation	CPSKQSSTESITEEF CCCCCCCCCCHHHHH	38.71	25072903
1189	Phosphorylation	SKQSSTESITEEFYR CCCCCCCCHHHHHHH	34.59	25072903
1191	Phosphorylation	QSSTESITEEFYRYM CCCCCCHHHHHHHHH	38.45	25072903
1195	Phosphorylation	ESITEEFYRYMLRDI CCHHHHHHHHHHHHH	12.24	25072903
1197	Phosphorylation	ITEEFYRYMLRDIER HHHHHHHHHHHHHHH	6.79	29759185
1209	Phosphorylation	IERDSRESASSRRSS HHHHCHHHHHHHCCC	32.13	-
1211	Phosphorylation	RDSRESASSRRSSQD HHCHHHHHHHCCCCC	33.39	-
1212	Phosphorylation	DSRESASSRRSSQDW HCHHHHHHHCCCCCC	31.28	-
1215	Phosphorylation	ESASSRRSSQDWTAG HHHHHHCCCCCCHHH	31.10	24719451
1216	Phosphorylation	SASSRRSSQDWTAGL HHHHHCCCCCCHHHH	30.28	27251275
1220	Phosphorylation	RRSSQDWTAGLLSPS HCCCCCCHHHHCCHH	21.09	-
1225	Phosphorylation	DWTAGLLSPSLRSPV CCHHHHCCHHHCCCC	19.93	-
1237	Phosphorylation	SPVCHRQSSMPDSRS CCCCCCCCCCCCCCC	28.67	29083192
1238	Phosphorylation	PVCHRQSSMPDSRSP CCCCCCCCCCCCCCC	26.46	24719451
1259	Phosphorylation	NVPIKANSLDGFAQN ECEEECCCCCHHHHC	32.47	28348404
1288	Phosphorylation	SSSGLCKSDSCLYRR CCCCCCCCCCCCCCC	33.49	-
1298	Phosphorylation	CLYRRGGTDHITNML CCCCCCCCCHHHHHH	27.51	26552605
1302	Phosphorylation	RGGTDHITNMLIHET CCCCCHHHHHHHHHH	15.91	26552605
1309	Phosphorylation	TNMLIHETWASSIEA HHHHHHHHHHHHHHH	16.51	26552605
1312	Phosphorylation	LIHETWASSIEALMR HHHHHHHHHHHHHHH	24.33	26552605
1313	Phosphorylation	IHETWASSIEALMRK HHHHHHHHHHHHHHC	19.39	26552605
1337	Phosphorylation	EADTEPVSGGSPSQA HCCCCCCCCCCHHHH	48.42	28348404
1340	Phosphorylation	TEPVSGGSPSQAEKC CCCCCCCCHHHHHHH	25.55	24719451
1367	Phosphorylation	PTLLVQESLDCPRKD CEEEEEEECCCCCCC	16.65	33259812
1380	Acetylation	KDSVTECKQPPVSSL CCCCCCCCCCCCCCC	60.65	20167786
1392	Phosphorylation	SSLSKTASLTNHSPL CCCCCCCCCCCCCCC	40.74	22912867
1474	Phosphorylation	DVVRGGDTAVSACQI HHHCCCCCCCHHHEE	32.03	23312004
1477	Phosphorylation	RGGDTAVSACQIHSD CCCCCCCHHHEECCC	22.36	23312004
1483	Phosphorylation	VSACQIHSDSLDTRD CHHHEECCCCCCCCC	30.44	28348404
1485	Phosphorylation	ACQIHSDSLDTRDVP HHEECCCCCCCCCCC	31.03	22912867
1488	Phosphorylation	IHSDSLDTRDVPEAE ECCCCCCCCCCCHHH	33.78	28348404
1587	Phosphorylation	KKILKGQSESTEAPA HCHHCCCCCCCCCCC	42.03	23312004
1589	Phosphorylation	ILKGQSESTEAPASG HHCCCCCCCCCCCCC	36.47	23312004
1590	Phosphorylation	LKGQSESTEAPASGP HCCCCCCCCCCCCCC	31.92	23312004
1595	Phosphorylation	ESTEAPASGPPTGTA CCCCCCCCCCCCCCC	51.26	23312004
1599	Phosphorylation	APASGPPTGTASPQR CCCCCCCCCCCCCCC	50.74	23532336
1601	Phosphorylation	ASGPPTGTASPQRSL CCCCCCCCCCCCCEE	26.83	23532336
1603	Phosphorylation	GPPTGTASPQRSLLV CCCCCCCCCCCEEEE	22.77	23312004
1678	Phosphorylation	IFHAVVQYCKMHEEQ HHHHHHHHHHHHHHC	5.17	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPKAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPKAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPKAP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPKAP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.