dbPTM

RUFY4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RUFY4_HUMAN
UniProt AC	Q6ZNE9
Protein Name	RUN and FYVE domain-containing protein 4
Gene Name	RUFY4
Organism	Homo sapiens (Human).
Sequence Length	571
Subcellular Localization
Protein Description
Protein Sequence	MAEEGAILKVTKDLRAAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTALRRQRGNMEPIHFVRSQDKLKTPLGKGRAFIRFCLARGQLAEALQLCLLNSELTREWYGPRSPLLCPERQEDILDSLYALNGVAFELDLQQPDLDGAWPMFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
136	Phosphorylation	REWYGPRSPLLCPER HCHHCCCCCCCCCHH	24.04	30631047
205	Phosphorylation	PKKIPAAYGGPENVQ CCCCCHHHCCCCCEE	25.40	24043423
216	Phosphorylation	ENVQIEDSHTSQAIC CCEEECCCCCCEEEE	18.84	24043423
218	Phosphorylation	VQIEDSHTSQAICLQ EEECCCCCCEEEEEE	26.87	24043423
219	Phosphorylation	QIEDSHTSQAICLQD EECCCCCCEEEEEEE	16.52	24043423
229	Phosphorylation	ICLQDAPSGQQLAGL EEEEECCCCCCCCCC	51.45	24043423
349	Phosphorylation	VQRLLMPSPRGAVEG HHHHHCCCCCCCCEE	17.17	24719451
478	Phosphorylation	AERRDAMYQEELGGQ HHHHHHHHHHHHCCC	17.94	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RUFY4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RUFY4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RUFY4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TPPC9_HUMAN	TRAPPC9	physical	26186194
TPPC9_HUMAN	TRAPPC9	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RUFY4_HUMAN

Related Literatures of Post-Translational Modification