| UniProt ID | CXD4_HUMAN | |
|---|---|---|
| UniProt AC | Q96KN9 | |
| Protein Name | Gap junction delta-4 protein | |
| Gene Name | GJD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 370 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell junction, gap junction. |
|
| Protein Description | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.. | |
| Protein Sequence | MEGVDLLGFLIITLNCNVTMVGKLWFVLTMLLRMLVIVLAGRPVYQDEQERFVCNTLQPGCANVCYDVFSPVSHLRFWLIQGVCVLLPSAVFSVYVLHRGATLAALGPRRCPDPREPASGQRRCPRPFGERGGLQVPDFSAGYIIHLLLRTLLEAAFGALHYFLFGFLAPKKFPCTRPPCTGVVDCYVSRPTEKSLLMLFLWAVSALSFLLGLADLVCSLRRRMRRRPGPPTSPSIRKQSGASGHAEGRRTDEEGGREEEGAPAPPGARAGGEGAGSPRRTSRVSGHTKIPDEDESEVTSSASEKLGRQPRGRPHREAAQDPRGSGSEEQPSAAPSRLAAPPSCSSLQPPDPPASSSGAPHLRARKSEWV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 240 | Phosphorylation | SPSIRKQSGASGHAE CHHHHHHCCCCCCCC | 39.09 | 24144214 | |
| 243 | Phosphorylation | IRKQSGASGHAEGRR HHHHCCCCCCCCCCC | 34.34 | 24144214 | |
| 251 | Phosphorylation | GHAEGRRTDEEGGRE CCCCCCCCCCCCCCC | 46.53 | 24719451 | |
| 277 | Phosphorylation | AGGEGAGSPRRTSRV CCCCCCCCCCCCCCC | 18.07 | 26853621 | |
| 281 | Phosphorylation | GAGSPRRTSRVSGHT CCCCCCCCCCCCCCC | 23.36 | 23090842 | |
| 282 | Phosphorylation | AGSPRRTSRVSGHTK CCCCCCCCCCCCCCC | 28.95 | 23090842 | |
| 285 | Phosphorylation | PRRTSRVSGHTKIPD CCCCCCCCCCCCCCC | 24.60 | 23090842 | |
| 288 | Phosphorylation | TSRVSGHTKIPDEDE CCCCCCCCCCCCCCH | 33.91 | 23090842 | |
| 296 | Phosphorylation | KIPDEDESEVTSSAS CCCCCCHHHHCCHHH | 50.08 | 23090842 | |
| 299 | Phosphorylation | DEDESEVTSSASEKL CCCHHHHCCHHHHHH | 16.95 | 23090842 | |
| 300 | Phosphorylation | EDESEVTSSASEKLG CCHHHHCCHHHHHHC | 29.14 | 23090842 | |
| 301 | Phosphorylation | DESEVTSSASEKLGR CHHHHCCHHHHHHCC | 26.84 | 23090842 | |
| 303 | Phosphorylation | SEVTSSASEKLGRQP HHHCCHHHHHHCCCC | 36.89 | 23090842 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CXD4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CXD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CXD4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CXD4_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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