ULK2_HUMAN - dbPTM
ULK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ULK2_HUMAN
UniProt AC Q8IYT8
Protein Name Serine/threonine-protein kinase ULK2
Gene Name ULK2
Organism Homo sapiens (Human).
Sequence Length 1036
Subcellular Localization Cytoplasmic vesicle membrane
Peripheral membrane protein . Localizes to pre-autophagosomal membrane.
Protein Description Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons..
Protein Sequence MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31SumoylationFRGRHRQKTDWEVAI
ECCCCCCCCCHHHHH		48.70-
39SumoylationTDWEVAIKSINKKNL
CCHHHHHHHHHHCCC		35.23-
104PhosphorylationLQAKGTLSEDTIRVF
HHHCCCCCHHHHHHH		33.01-
148PhosphorylationYANRRKSSVSGIRIK
ECCCCCCCCCCCEEE		24.28-
150PhosphorylationNRRKSSVSGIRIKIA
CCCCCCCCCCEEEEE		30.3727966365
231PhosphorylationMFYEKNRSLMPSIPR
HHHHHCCCCCCCCCC		38.1123403867
235PhosphorylationKNRSLMPSIPRETSP
HCCCCCCCCCCCCCH		31.1223403867
323PhosphorylationIQEENLSSPPLGPPN
HHHCCCCCCCCCCCC		33.4319835603
331PhosphorylationPPLGPPNYLQVSKDS
CCCCCCCCEEECCCC		12.3219835603
378PhosphorylationGTAGRRASNEFLVCG
CCCCCCCCCCEEEEC		34.7728348404
425PhosphorylationTSTASSGTNVHGSPR
HCCCCCCCCCCCCCC		35.70-
430PhosphorylationSGTNVHGSPRSAVVR
CCCCCCCCCCCEEEE		11.4030624053
441PhosphorylationAVVRRSNTSPMGFLR
EEEECCCCCCCCCCC		35.1428348404
506PhosphorylationHDSRSRNSSGSPVPQ
CCCCCCCCCCCCCCC		34.6627251275
507PhosphorylationDSRSRNSSGSPVPQA
CCCCCCCCCCCCCCC		47.0027251275
509PhosphorylationRSRNSSGSPVPQAQS
CCCCCCCCCCCCCCC		25.3625921289
516PhosphorylationSPVPQAQSPQSLLSG
CCCCCCCCHHHHHCC		28.1125921289
528PhosphorylationLSGARLQSAPTLTDI
HCCCCCCCCCCHHHH		40.5928857561
531PhosphorylationARLQSAPTLTDIYQN
CCCCCCCCHHHHHHC		41.8427251275
570PhosphorylationPQPSRPGSLGTSPTK
CCCCCCCCCCCCCCC		26.7229514088
573PhosphorylationSRPGSLGTSPTKHLG
CCCCCCCCCCCCCCC		36.5029514088
574PhosphorylationRPGSLGTSPTKHLGS
CCCCCCCCCCCCCCC		28.8629514088
576PhosphorylationGSLGTSPTKHLGSSP
CCCCCCCCCCCCCCC		30.7529514088
581PhosphorylationSPTKHLGSSPRSSDW
CCCCCCCCCCCCCCC		43.4629514088
582PhosphorylationPTKHLGSSPRSSDWF
CCCCCCCCCCCCCCC		23.6429514088
585PhosphorylationHLGSSPRSSDWFFKT
CCCCCCCCCCCCCCC		35.7129514088
586PhosphorylationLGSSPRSSDWFFKTP
CCCCCCCCCCCCCCC		39.8929514088
592PhosphorylationSSDWFFKTPLPTIIG
CCCCCCCCCCCEECC		25.5423312004
596PhosphorylationFFKTPLPTIIGSPTK
CCCCCCCEECCCCCC		32.6729978859
600PhosphorylationPLPTIIGSPTKTTAP
CCCEECCCCCCCCCC		20.9829978859
602PhosphorylationPTIIGSPTKTTAPFK
CEECCCCCCCCCCCC		42.6022985185
604PhosphorylationIIGSPTKTTAPFKIP
ECCCCCCCCCCCCCC		30.5723312004
605PhosphorylationIGSPTKTTAPFKIPK
CCCCCCCCCCCCCCC		33.6123312004
613O-linked_GlycosylationAPFKIPKTQASSNLL
CCCCCCCCCCCCCHH		24.8228657654
667PhosphorylationSKAVFGRSVSTGKLS
HHHHHCCCCCCCCCC		22.3129514088
669PhosphorylationAVFGRSVSTGKLSDQ
HHHCCCCCCCCCCCC		32.4624719451
670PhosphorylationVFGRSVSTGKLSDQQ
HHCCCCCCCCCCCCC		35.8629514088
688PhosphorylationPICRHQGSTDSLNTE
CCCCCCCCCCCCCCC		23.5928348404
689PhosphorylationICRHQGSTDSLNTER
CCCCCCCCCCCCCCC		36.1128348404
691PhosphorylationRHQGSTDSLNTERPM
CCCCCCCCCCCCCCC		24.4928348404
694PhosphorylationGSTDSLNTERPMDIA
CCCCCCCCCCCCCCC		38.3728348404
726PhosphorylationSSKAVLFTVGSPPHS
CCCEEEEECCCCCCC		21.5725850435
729PhosphorylationAVLFTVGSPPHSAAA
EEEEECCCCCCCCCC		30.8125850435
733PhosphorylationTVGSPPHSAAAPTCT
ECCCCCCCCCCCCCC		25.9425850435
750PhosphorylationFLRTRTTSVGPSNSG
EEEECCCCCCCCCCC		25.1927251275
754PhosphorylationRTTSVGPSNSGGSLC
CCCCCCCCCCCCCCE		37.3927251275
771PhosphorylationSGRVCVGSPPGPGFG
ECCEECCCCCCCCCC		13.9225850435
779PhosphorylationPPGPGFGSSPPGAEA
CCCCCCCCCCCCCCC		37.0925850435
780PhosphorylationPGPGFGSSPPGAEAA
CCCCCCCCCCCCCCC		35.1825850435
789PhosphorylationPGAEAAPSLRYVPYG
CCCCCCCCCCCCCCC		22.2827732954
826PhosphorylationMEREHTDTLRHLNVM
HHHHCHHHHHHHHHH		27.18-
844PhosphorylationTECVLDLTAMRGGNP
HHHHHHHHHHCCCCH		20.34-
922AcetylationTAVKQVVKNLNERYK
HHHHHHHHHHHHHHH		57.787665197
1018PhosphorylationDIENVHKYKCSIERR
HHCCHHHHCCCHHHH		11.4422468782
1027PhosphorylationCSIERRLSALCHSTA
CCHHHHHHHHHHCCC		19.86-
1032PhosphorylationRLSALCHSTATV---
HHHHHHHCCCCC---		20.8122468782
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1027SPhosphorylationKinasePRKACAP17612
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ULK2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ULK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYGP1_HUMANSYNGAP1physical
15014045
DPOA2_HUMANPOLA2physical
16169070
NASP_HUMANNASPphysical
16169070
LC7L2_HUMANLUC7L2physical
16169070
SETB1_HUMANSETDB1physical
16169070
RBCC1_HUMANRB1CC1physical
20562859
ZNF32_HUMANZNF32physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ULK2_HUMAN

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Related Literatures of Post-Translational Modification

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