| UniProt ID | ADA1D_HUMAN | |
|---|---|---|
| UniProt AC | P25100 | |
| Protein Name | Alpha-1D adrenergic receptor | |
| Gene Name | ADRA1D | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 572 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.. | |
| Protein Sequence | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTFRDLLSV ------CCHHHHEEC | 27.64 | 23663014 | |
| 8 | Phosphorylation | MTFRDLLSVSFEGPR CCHHHHEECCCCCCC | 24.02 | 23663014 | |
| 10 | Phosphorylation | FRDLLSVSFEGPRPD HHHHEECCCCCCCCC | 17.76 | 23663014 | |
| 65 | N-linked_Glycosylation | GAGSGEDNRSSAGEP CCCCCCCCCCCCCCC | 41.24 | UniProtKB CARBOHYD | |
| 82 | N-linked_Glycosylation | AGAGGDVNGTAAVGG CCCCCCCCCCCEECC | 47.00 | UniProtKB CARBOHYD | |
| 201 | Phosphorylation | RYVGVRHSLKYPAIM CCCCHHHCCCCCCCC | 18.91 | 50563801 | |
| 228 | Phosphorylation | WVVALVVSVGPLLGW HHHHHHHHHHHHCCC | 17.55 | 68705047 | |
| 300 | Phosphorylation | KRERGKASEVVLRIH CCCCCCCCEEEEEEE | 34.12 | - | |
| 323 | Phosphorylation | DGAHGMRSAKGHTFR CCCCCCCCCCCCCCH | 25.99 | - | |
| 328 | Phosphorylation | MRSAKGHTFRSSLSV CCCCCCCCCHHHHHH | 29.43 | - | |
| 331 | Phosphorylation | AKGHTFRSSLSVRLL CCCCCCHHHHHHHHH | 31.29 | - | |
| 332 | Phosphorylation | KGHTFRSSLSVRLLK CCCCCHHHHHHHHHH | 22.02 | - | |
| 334 | Phosphorylation | HTFRSSLSVRLLKFS CCCHHHHHHHHHHHC | 13.72 | 24719451 | |
| 419 | S-palmitoylation | AFLRLLRCQCRRRRR HHHHHHHHHHHHHHH | 4.52 | - | |
| 442 | Phosphorylation | GHHWRASTSGLRQDC CHHHCCCCCCCCCCC | 26.32 | - | |
| 477 | Phosphorylation | PDPEPPGTPEMQAPV CCCCCCCCHHCCCCH | 23.11 | - | |
| 486 | Phosphorylation | EMQAPVASRRKPPSA HCCCCHHHCCCCCHH | 32.62 | - | |
| 492 | Phosphorylation | ASRRKPPSAFREWRL HHCCCCCHHHHHHHH | 48.87 | - | |
| 507 | Phosphorylation | LGPFRRPTTQLRAKV CCCCCCCCHHHHHHH | 25.93 | - | |
| 515 | Phosphorylation | TQLRAKVSSLSHKIR HHHHHHHHHHHHHHH | 25.51 | 22468782 | |
| 516 | Phosphorylation | QLRAKVSSLSHKIRA HHHHHHHHHHHHHHH | 36.56 | - | |
| 518 | Phosphorylation | RAKVSSLSHKIRAGG HHHHHHHHHHHHHCH | 25.36 | - | |
| 543 | Phosphorylation | RSEVEAVSLGVPHEV CCHHEEEECCCCHHH | 26.84 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 300 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 300 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| 323 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 323 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| 332 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 332 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| 334 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 334 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| 516 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 516 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| 518 | S | Phosphorylation | Kinase | GRK2 | P25098 | PSP |
| 518 | S | Phosphorylation | Kinase | PKCA | P17252 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADA1D_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADA1D_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ACTA_HUMAN | ACTA2 | physical | 18468998 | |
| AMFR_HUMAN | AMFR | physical | 18468998 | |
| CKAP4_HUMAN | CKAP4 | physical | 18468998 | |
| DTNA_HUMAN | DTNA | physical | 18468998 | |
| ERLN1_HUMAN | ERLIN1 | physical | 18468998 | |
| ERLN2_HUMAN | ERLIN2 | physical | 18468998 | |
| GOPC_HUMAN | GOPC | physical | 18468998 | |
| SNTB2_HUMAN | SNTB2 | physical | 18468998 | |
| SNTB1_HUMAN | SNTB1 | physical | 18468998 | |
| UTRO_HUMAN | UTRN | physical | 18468998 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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