CTSRD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTSRD_HUMAN
• UniProt AC: Q86XM0
• Protein Name: Cation channel sperm-associated protein subunit delta
• Gene Name: CATSPERD
• Organism: Homo sapiens (Human).
• Sequence Length: 798
• Subcellular Localization: Cell projection, cilium, flagellum membrane ; Single-pass type I membrane protein . Specifically located in the principal piece of sperm tail.
• Protein Description: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane..
• Protein Sequence: MLMLMLVAAVTMWLRPLVTAQLCRSRTVRTGKVFNLIQDVQGDRLYFHPTTTRLIKHPCEKNIALYLGKQVFFTMDNFETSLLPFTIPTSMQVGVPEVTSAHFAGSLLLLVVDQKVYIYDYENNSWSMSLGIKHPVTHVSGDNCCYTGSLFCVHVSNLVFAYFRGDQISQTYIYYSNTGGFSFWKYHYDRQAEIIGSLGGIFHFFSLSQVAMLVVNQGKGMFKYSDHPLNRSFGLSFDYNGTLDILIAPGQRGILLLWFENSLLFSHNAGQLVDTVRVKKGDQTLFSSIFEAKITIHNIAVTENELAVITREDNLYYGNLGIVPSSIIKFADQYIWSEDVALMFRSPGTLEILTPLRDTAFPAFDFQKCLVNIQALLMDPELHVGKCKIEFLTGEFIYRMYTIDMHSQLELTASLIPQPGTSLIPLVMVSNPHSLGFQATFYENGYTSDGNTKYKLDIFLKQQQHWGRTDSNFTSSLKKATMSTLTVDIANKEISCVDIKPLSTLISVGCDLDKKIVIQNKVSACSMGILDPLTLQDNYSFIIEKEFYDPGFQGQQSSEDLHVFYSYQQLGCPLLVYYDTLWKPVVELWRKDSFQEVIDAEYVLLEVNGQFSYSYSLTAQSAMCTSQPQNWTTMIKEFGGPFFWNRENYVSCHDPNNNAPLRWPDVQYQILGGRTANQIIFGHNGFYVFYISIVDPYYSYCQLETIFSIYVYGAFPVQLVSAGVVILLIISSILGSVWLAYKTPKLLRTARGRRIKKCATQLCRRCKTVCQFRASATARAGTEPPGRHRTPHGGRSDH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LMLVAAVTMWLRPLV HHHHHHHHHHHHHHH	9.63	24043423
19	Phosphorylation	MWLRPLVTAQLCRSR HHHHHHHHHHHHHCC	19.17	24043423
240	N-linked_Glycosylation	FGLSFDYNGTLDILI CCEEEECCCEEEEEE	38.53	UniProtKB CARBOHYD
264 (in isoform 2)	Phosphorylation	-	4.09	22210691
281 (in isoform 2)	Phosphorylation	-	26.92	22210691
317	Phosphorylation	TREDNLYYGNLGIVP ECCCCEEECCCCCCC	11.60	22817900
326	Phosphorylation	NLGIVPSSIIKFADQ CCCCCCHHHHHHHHH	23.43	24719451
471	Phosphorylation	QHWGRTDSNFTSSLK CCCCCCCCCHHHHHH	32.98	29759185
472	N-linked_Glycosylation	HWGRTDSNFTSSLKK CCCCCCCCHHHHHHH	47.20	UniProtKB CARBOHYD
475	Phosphorylation	RTDSNFTSSLKKATM CCCCCHHHHHHHHHE	29.54	29759185
476	Phosphorylation	TDSNFTSSLKKATMS CCCCHHHHHHHHHEE	40.94	29759185
481	Phosphorylation	TSSLKKATMSTLTVD HHHHHHHHEEEEEEE	22.12	29083192
483	Phosphorylation	SLKKATMSTLTVDIA HHHHHHEEEEEEEEC	18.86	29083192
484	Phosphorylation	LKKATMSTLTVDIAN HHHHHEEEEEEEECC	18.67	29083192
486	Phosphorylation	KATMSTLTVDIANKE HHHEEEEEEEECCCC	19.07	29083192
538	N-linked_Glycosylation	DPLTLQDNYSFIIEK CCCCCCCCEEEEEEE	22.76	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTSRD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTSRD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTSRD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BPL1_HUMAN	HLCS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.